Over the last few decades, the occurrence of micropollutants on the surfaces, wastewater and tap water has become an increasing problem. Pharmaceutical micropollutants are compounds commonly present in waters in traces, ranging from a few ng/L to several μg/L. Due to their increasing use, they are continuously entering into the environment, which leads to harmful effects to humans and water organisms. Conventional methods for wastewater treatment have proven insufficiently effective for their removal. Heterogeneous photocatalysis has emerged as a effective technology for degradation wide range of organic pollutants, while at the same time is environmentally and economically acceptable process. TiO2 is the most commonly used photocatalyst. Using TiO2, it is achieved a high percentage of mineralization of organic pollutants due to corrosion resistance, chemical stability and high photocatalytic acitivity in UV region. Inorganic ions and natural organic matter distributed in different water matrix can affect at heterogeneous photocatalysis. Chloride, sulphate, bicarbonate, carbonate, nitrate, phosphate ions and humic substances are the most common components of natural waters. Inorganic ions can adsorb on the surface of the photocatalyst and act as scavangers to reactive radicals species, while dissolved organic matter in addition to that can also attenuation the incident light in aqueous solution and be photosensitizers. The presence of organic and inorganic matrix in water environment can increase the degradation of pharamecuticals, but in many more cases they act as inhibitors of pharmaceuticals degradation.