Lurasidone hydrochloride is an antipsychotic drug used for the treatment of shizophrenia and bipolar disorder. It is characterized by low solubility in intestinal fluids and thus poor absorption of drug in the organism. Solubility improvement of lurasidone hydrochloride and thus the bioavaliability of drug, means its better pharmacological response in the treatment of psychotic disorders. Therefore, in this research, there is an effort to mechanochemically activate this drug. Promising approach for drug solubility enhacement of poorly soluble drugs is preparation of amorphous solid dispersions. In this research, solid dispersions of hydrophobic lurasidone-hydrochloride in a hydrophilic polymer carrier poly(vinyl-pirolidonne), are to be made, in different ratios, by using principles of mechanochemistry. Obtained solid dispersions were characterized by differential scanning calorimetry, X-ray powder difraction analysis and infrared spectroscopy. Solid dispersions and granulated mixtures of excipients: mannitol, sodium croscarmellose and microcrystalline cellulose were used in the preparation of tablets with 8 mm in diameter. Characterization of tablets involved testing the mass uniforimity and its disintegration. Release profiles indicate improved solubility and faster drug release from tablets prepared from mechanochemically treated samples in comparison to those containing pure untreated lurasidone hydrochloride (LRS HCl).