Crystallization is one of the most used processes for obtaining and purifying active pharmaceutical ingredients (APIs) in the pharmaceutical industry. Crystallization from solution is most often carried out. When carrying out the crystallization process, it is necessary to choose suitable solvents, determine the solubility of the API, the temperature range in which the process is carried out and the method of achieving supersaturation. All the mentioned factors affect the granulometric properties of the crystal and the eventual occurrence of polymorphism. As an aid in adjusting the conditions of the crystallization process and other engineering processes, various programs are used to speed up the selection of the necessary process conditions in order to obtain the desired results. In this paper, an overview of crystallization methods and important factors that affect it, methods of crystal characterization and the use of the Dynochem program is presented. The paper presents the determination of the solubility of the API and the comparison of the results obtained using Dynochem. Crystallization by cooling was performed, during which the effect of the solvent system on the granulometric properties of the resulting crystals and their internal structure was examined. In addition, preliminary research was conducted for the implementation of spherical crystallization. Using Dynochem program, a system of three solvents (solvent, antisolvent and bridging solvent) was selected, which are considered suitable for carrying out spherical crystallization. After the characterization of the obtained crystals, it can be concluded that the acetone-water system is more suitable to work with than the ethanol-water system because larger crystals are obtained from the acetone system, which are more suitable for further use in research. Although spherical crystallization experiments were performed for the selected solvent system and compositions within the heterogeneous region, no crystals were obtained. It can be assumed that, in addition to thermodynamic conditions, it is necessary to adjust the kinetic parameters of the process.