Aliphatic polyesters, polycaprolactone (PCL) and polylactide (PLA) are one of the most biodegradable polymers. They have wide application in medicine such as in tissue engineering, controlled delivery of drugs, orthopedics... Mixtures of polycaprolactone (PCL), which is a flexible polymer with high stiffness polymer lactide (PLA) show interesting properties for a variety of physical properties and biodegradability. Great importance have the complementarily of these two biocompatible polymers because in this way depending on the proportion of each polymer can be controlled to adjust the properties of a mixture. The main objective of this study was to investigate the influence of hydroxypropyl cellulose (HPC) as hydrophilic components on degradation rate and properties of PCL/PLA blend. The hydrolytic degradation is carried out in a solution of HBSS in controlled environment at 37 °C through the period of six weeks. PCL and PLA polymers and PCL/PLA (50/50) and PCL/PLA / HPC (45/45/10) blends were prepared by melt blending in a Brabender plasticorder. The hydrolytic degradation is carried out on molded plates of defined dimensions. Hydrolytic stability was assessed by periodically measuring sample weight loss. Changes in surface properties were monitored by measuring the contact angle with water and structural analysis by using FTIR-ATR spectroscopy. After hydrolytic degradation during six weeks, mechanical (tensile test) and thermal properties (DSC and TGA), and surface morphology (SEM) were investigated. It was found that HPC had significant influence on hydrolytic degradation rate and properties of PCL/PLA blend. High hydrophility of HPC polymer allows faster diffusion of water into material interior which in turn affects degradation rate of PCL/PLA blends.