Spray drying, amongst other technologies and fact that it is a continuous manufacturing process, is a very useful method for manufacturing of amorphous solid materials. This is mainly due to the possibility of fast solvent evaporation that leads to a rapid transformation of solution to a solid state. Besides evaporation kinetics, there are various process parameters that influence physical and chemical characteristics of such obtained material. In this work, the possibility of obtaining a stable amorphous structure of the active pharmaceutical ingredient as well as stable solid dispersion with a polymer in a spray-dryer was examined. Taking into account solubility of all ingredients, their crystalization and chemical stability, influence of material of construction on their stability, optimal system for spray drying process was chosen. A solution of the hydrochloride crystalline structure of the active pharmaceutical ingredient in a mixture of water and acetonitrile was dried at different temperatures, nozzle configurations and flow rates of nitrogen used for atomization, as well as the flow rates of the solution. The influence of the process conditions on the properties of the product was analyzed. The final dried products were characterized and identified with a variety of analytical and physical methods. The results showed that a stable amorphous structure of the high purity active pharmaceutical ingredient is obtained with a spray drying, and that the optimal conditions of the process are defined. The amorphous structure is stable at temperatures below 200 °C when it is transformed into a new crystal structure. Solid dispersion showed improved stability compared to pure amorphous active ingredient. Conditions of high relative air humidity lead to partial transformation. Spray drying of the solution of the active pharmaceutical ingredient from the laboratory drier Buchi 290 to pilot drier 53 PSD CC Anhydro was investigated. Obtained results show that the most similar drying conditions were achieved when larger nozzle diameters were used in Buchi, and in Anhydro a combination of higher drying temperature with lower nozzle pressure, or lower drying temperature with higher pressure. Even the highest nozzle pressures in Anhydro could not produce similar drying conditions as obtained in laboratory scale by the use of smaller nozzle diameters.