Statins are pharmaceuticals used to lower cholesterol in the blood and to prevent cardiovascular diseases. Enzyme 2-deoxyribose-5-phosphate aldolase (DERA) is the only known enzyme that participates in the highly selective aldol addition reaction in which lactol, an important precursor for statin side chain production, is formed. DERA catalyzes the synthesis reaction of (3R, 5R)-6-chloro-3,5-dihydroxyhexanal (lactol) by double aldol addition of acetaldehyde (AA) and chloroacetaldehyde (CAA). The aim of this work was to carry out the synthesis of statins with an immobilized enzyme DERA in different types of continuous reactors with volumes of 300 and 600 μL and in series connected reactors (2 x 300 μL), i.e. examine the influence of different volumes and flow rates on formation of the intermediate product, 4-chloro-3-hydroxybutanal (4 C-Cl) and the product, 6-chloro-3,5-dihydroxyhexanal (6 C-Cl). The reaction in the reactors was carried out at flow rates; 2, 5 and 7 μL/min. By comparing the process indicators in the reactors, as the best performance parameters were obtained: XCAA,max = 99.98 % and XCAA,max = 96.93 % in experiments E2-1 (V = 600 μL, q = 2 μL/min) and E3-1 (V = 2 x 300 μL, q = 2 μL/min) at a longer retention time (87.0 min), while the highest productivity of the process in the amount of 1.99 mM/min was achieved in experiment E1-3 (V = 300 μL, q = 7 μL/min) at a retention time of 12.4 min.