Some of the most important requirements of today's market are to increase the quality of products while simultaneously reducing costs, time of development and production. Additive manufacturing offers solutions to these requirements, and in recent years, low-budget 3D printers based on the Fused deposition modeling (FDM / FFF) are intensively developing. In order to produce high-quality prototypes / products with 3D printing, it is necessary to know the conditions in which they will be applied, which define their required properties, and to explore the influence of certain 3D print parameters on the final product properties. The aim of this study is to examine the influence of 3D printing parameters on capsule shell properties that can be used as an oral dosage form. 16 experiments were made using split-plot design. The influence of the capsule angle, the extruder temperature, and the printing speed on the capsule shell quality was tested. Shell quality was rated visually by stereomicrography by classifying the capsules in categories 1 to 5 and monitoring the release time of the dye from the capsule. 500 mL of 0.1 M HCl, pH value 1.2, was used as medium. The medium temperature was set at 37 ± 0.5 ° C, and 74 mm diameter paddles were used for mixing. Impact study of capsule angle, extruder temperature, and printing speed on the shell quality was carried out in the Design Expert 11 software. The variance was analyzed by the REML method. The impact of input factors on each response has been separately analyzed. The results of statistical data processing have shown that lower temperature, lower print speed, and angle of 0° will give the capsule a better shell and thus a longer release time. The solution found, as the optimum of the process resulting with shell that has the quality 5, gives an angle of 0°, an extruder temperature of 180 °C and a printing speed of 26.3 mm s^–1.