Wide-ranging pharmaceuticals are used on daily basis in both human and veterinary medicine, but due to the inability to remove them by conventional wastewater treatment methods, either from industrial or municipal wastewater, very often they end up in drinking water, as well as in sediment and in soil. Therefore the necessity for the development of current wastewater treatment system is even more enhanced and advanced oxidation methods are considered as a new promising method. There should be noted that the photoxidation process which consider application of irradiation energy in UV-C spectra in combination with strong oxidizing agent results with highly efficient degradation of different organic pollutants. The aim of this study was to investigate the application of two photooxidation processes, with different oxidizing agents, hydrogen peroxide and peracetic acid for the degradation of the model wastewater that consist pharmaceutical carbamazepine as a pollutant. In this work, Design of experiments and Response surface methodology were used for the investigation of the process parameters on the efficiency of the process, as well as determination of the optimal process conditions. It is estimated that the pH value of solution and the concentration of oxidant have almost even level of importance and influence for the process, while the optimal pH =3 and [H2O2] = 9 mM. On the other hand, pH value of the solution has showed higher level of importance and influence for the process than the concentration of oxidant, while the optimal pH = 3 and [PAA] = 5 mM. Experimental results shows that the degradations of the carbamazepine by photooxidation in both cases can be described with first order kinetics with belonging constants: 46,2·10^-3 s^-1 and 31,8·10^-3 s^-1 and mineralization with second order kinetics with belonging constants: 5,3·10^-3 s^-1 and 4,7·10^-5 s^-1