During the long-term control of the truck with the mobile workers, fatigue, drowsiness, attention and alertness fluctuations occur that increase the frequency of errors, and potentially cause severe consequences for the safety of all participants in logistics processes in the transport logistics segment. The paper presents and describes in detail the dominant factors of fatigue, where a man who in the basic division of factors of the transport system, a driver-traffic agenttraffic environment, makes the weakest link and as such is subject to the influence of various negative factors that can negatively affect performance in mobile workers. The tasks of mobile workers that require continuous attention must be planned so that, except for working periods, they include rest periods to reduce the risk of accidents, which otherwise increases in the function of increasing fatigue. In this segment, the importance of properly organizing shifts and driving schedules is crucial, both for mobile workers and for all road users. In addition to the organization of shift work, it is proposed to reduce the occurrence and / or consequences of fatigue in logistics processes using advanced prevention systems and /or the detection of fatigue installed in trucks, ie. higher level of fleet automation, and by means of more simultaneous interventions in the transport and work environment of mobile workers. Among these, it has been explored how, by applying the IRAP methodology, the selection of locations of traffic accident for which fatigue can be a potential cause can be significantly facilitated, and all for the purpose of preventing traffic accidents, but also to reduce the proportion of factors in the group „human factor “.