Topology optimization in the product development context is one of the most powerful modern engineering tools for improving mechanical properties of structures. The widespread application of topology optimization started in parallel with aditive manufacturing development in the 1980s. By combining additive manufacuring processes with unusual and organic geometric shapes of topologically optimized constructions, the impossibility barrier in manufacturing high complexity products using conventional manufacturing procedures has been overcome. This paper serves as an example of optimizing the structure of a heavy-duty shelf bracket with the application of four different materials and their comparison. At the same time, it is foreseen that the bracket will be made using additive manufacturing, and for this purpose, certain restrictions have been applied to the simulation model. The theoretical part of the paper includes an introduction to the basics of topology optimization as a design method, including its mathematical basis, and a description of the necessary steps that are an integral part of the optimization process. Additionally, the topology optimization procedure in the Altair Inspire software package is described with certain guidelines that must be followed. Furthermore, a general introduction to additive manufacturing and the aspects that must be taken into account in order to make its use profitable in relation to commercial manufacturing processes are given. The principles of designing polymer and metal products for the use of additive manufacturing processes are described in detail as well. In the practical part of the work, the process of topology optimization of the heavy-duty bracket using the Altair Inspire program package is presented. The initial structure of the support and the universal load used in the process are defined. The properties of four selected materials for application during topological optimization are presented and the obtained optimization results are presented. The bracket made of each material used is subjected to two different optimization iterations, aiming to minimize mass and maximize stiffness. On a sample of successfully performed load simulations with a total duration of approximately 43 hours, satisfactory results were obtained and their mutual comparison was made. At the end of the paper, certain suggestions were given regarding the further development of the issue.