This thesis presents the development of a robotic stereotactic frame intended for application in neurosurgery. The development of the medical technology focuses on improving accuracy of neurosurgical procedures, decreasing negative patient experience, faster recovery and better overall clinical outcomes. Robotics and the development of the computer sciences represent a logical solution to the issues regarding the improvement in the performance of medical procedures. The analysis of the standard medical equipment applied in stereotactic neurosurgery marks the beginning of the development of the system, more precisely of the Leksell stereotactic system. The paper describes the development of the concept of a robotic stereotactic device, the design of robotic stereotactic framework and provides an analysis of the developed system. The content of the diploma thesis can be divided up into several parts. The first part offers an introduction into the field of robotics and neurosurgery. It describes the technology development in medicine and presents the current scope in the development of neurosurgical robotic systems. The second part of the thesis presents the development of the concept of stereotactic device intended for the application in neurosurgery. It describes the kinematic robot structure and several kinematic device concepts. The drafting process ends with an evaluation and selection of the optimal solution for the constructional elaboration. Then it was necessary to develop a robotic stereotactic frame for the selected concept which is discussed in the next part of this thesis. Design of the robotic stereotactic frame is a part of the thesis which presents the axis configurations that were selected and element calculations that were performed. Upon selecting the right combinations of the elements to drive the robot axes, the next phase included the system drafting and elaboration. A system was developed for the selected elements as well as its working principle, description of which is enclosed with the thesis. In the next stage the accuracy of the positioning is analysed, the characteristics of the encoder are presented and the security factors described. The final part of the thesis represents the conclusion which describes the contributions of the paper and suggests further possibilities for the system development.