This final paper describes digitization, Industry 4.0, Healthcare 4.0, the Internet of Things, the Internet of Services, the concept of a smart hospital and the healthcare trends itself. As part of the final paper task, it was necessary to explain and describe how concepts and technologies that are key in Industry 4.0 and digitization can be implemented in healthcare facilities. The concepts and application of Industry 4.0 and digitization are explained in detail, and there are given examples of existing implementation. The very application of technologies and trends demanded by Industry 4.0 and digitization is very challenging, because in healthcare almost all segments meet the socioeconomic factors that are essential in order to perform. When applying the technology and principles of digitization and Industry 4.0 with all the accompanying processes, the concept of a smart hospitals is gained. At the very beginning of the final paper, the health system of the Republic of Croatia was processed through statistical indicators and trends in order to present the state of the health system, and thus the need to improve the health processes. There is a lot of potential and need for restructuring in Croatian health care due to demographic opportunities that exert pressure on the existing health system organization. The middle section of the paper explains concept of a smart hosptal and are given the examples of technologies used in them. The principles of treatment and the organization of a smart hospital are also mentioned. The principles for introducing technologies of Industry 4.0 into healthcare facilities and how to be safe in protecting the patient’s privacy are also explained. The goal of all technologies is to transform healthcare institutions, primarily hospitals, into more sustainable and more efficient systems to provide maximum health care to the patient. The third part of the paper deals with the application of elaborated theoretical knowledge at the cardiology ambulance of the Zagreb Health Center. By capturing the team’s work process and the problems encountered, conclusions and suggestions of process improvements have been made and analysis of the new proposed process. The conclusion of the final work is that Industry 4.0 with complementary tools and digitization have amajor role in transforming health systems. The need for the implementation of smart hospital elements to adapt the Croatian health system to the needs of patients is the ubiquity of any medical institution.