The aim of this master's thesis was to choose the optimal material for the wheelchair frame. In the introductory part of the work, the function of the wheelchair is described. According to the selected group of users, the needs and requirements for the wheelchair frame were obtained. The requirements analysis identified the structural requirements that were used to create the wheelchair model. On the most critical point of the wheelchair was made an analytical calculation. According to the calculation results, a pre-selection of materials was made to narrow down the area of the optimal material selection. The requirements on the wheelchair frame, obtained from the user, are mapped to the material properties. The factor of importance for each property was calculated using the digital-logic method. Polymer composite with carbon fibers was chosen as the optimal material for the wheelchair frame using the method of properties influence. Regardless of the results obtained by the implemented methods, due to the high cost of the composite material, aluminum alloy was chosen as the wheelchair frame material for the selected age group. Aluminum alloys proved to be a material that provides a balance between quality and price, which were the most important required factors when considering. To confirm that the selected material and the model made for the target group can withstand the given load, a numerical analysis was carried out. It was determined that the obtained maximum stress does not exceed the value of the permissible stress, with sufficient safety.