Cobalt-chromium (Co-Cr) alloys are most often used in the production of metal parts of prosthetic replacements for fixed dental prostheses such as crowns and bridges and various orthopaedic implants because they possess an excellent combination of mechanical properties, wear and corrosion resistance combined with good biocompatibility. Traditional methods of casting and milling supported by computer systems (CAD-CAM) with subsequent processing (heat treatment, grinding, etc.) are used in production of fixed prosthetic replacements. Additive technologies, especially selective laser melting (SLM), have been trying to overcome the shortcomings of traditional production processes in the last few years. Therefore, today there are large investments in the development of technologies and devices for additive manufacturing intended specifically to produce dental parts, and devices for additive manufacturing using SLM. The SLM process is complex because it contains many parameters that affect the structure and properties of the consolidated material. The main purpose of this scientific research was to determine the influence of SLM parameters on the structure and properties of the EOS CoCr SP2 dental alloy. The research aims to contribute to the understanding of the influence of the parameters of the SLM procedure on the structure and properties of the dental Co-Cr alloy and the following hypotheses are assumed: Through laboratory tests and material characterization is possible to determine the changes and connection of the structure and properties of the dental Co-Cr alloy depending on the used parameters of the SLM procedure by applying the central composite design. It is possible to quantify the significance of the parameters of the SLM procedure on the structure and properties of the dental Co-Cr alloy, the magnitude of their action and interaction. The research conducted in this doctoral thesis is described in eight chapters. The influence of certain input parameters of SLM on the structure and properties of consolidated dental Co-Cr alloys and their interaction is an important area for research, which includes methods of modern scientific research work. The preparation of the research includes the definition of all scientific research elements necessary for the successful implementation of the experiment. Primarily, it refers to the type and composition of the powder material from which the samples were made, the definition and characterization of the structure that was carried out and provided information on the relationship between structure and properties. Special emphasis is placed on the definition and selection of standards for the testing of manufactured samples by SLM, and the types of laboratory tests, shapes, and dimensions of the samples were defined. The number of samples for testing was determined by applying a central composite design, which developed a model that describes the process if the studied factors affect the process, and if the results of the test were of acceptable accuracy and precision. A centrally composite design was applied to obtain as much information as possible about the installed system with minimal costs. The experimental part of the work includes the production of samples on the SLM device of the German manufacturer Aconity 3D GmbH, AconityMINI with complete freedom of access to all production parameters. The most significant input parameters of SLM that are varied are laser beam power, scanning speed, and base plate preheating temperature. Two groups of samples were made: one for testing the mechanical properties, and the other for structure characterization. Characterization of the structure was done in the laboratories of the Faculty of Mechanical Engineering and Naval Architecture in Zagreb and the Institute of Metal Materials and Technology in Ljubljana. The characterization also included metallographic preparation of samples and macro and microstructure analysis. These analyses include light and electron microscopy, which determined qualitative and quantitative microstructural parameters and the possible existence of porosity, inclusions, cracks, or other defects in the structure. Using other modern methods of characterizing the structure of the material, specifically Energy Dispersive Spectroscopy (EDS) or Wavelength-Dispersive Spectroscopy (WDS) analysis, Electron Backscatter Diffraction (EBSD) method, a microanalysis of the chemical composition of the material and an analysis of the crystallographic orientation was carried out. Testing of other properties of the consolidated Co-Cr alloy is focused on properties important for dental applications, which include static tensile tests to determine conventional yield strength Rp0,2 and elongation ε, impact fracture tests to determine toughness KVa, and three-point bending tests to determine flexural strength Rms. Analyses of the obtained results determined the significance of the variable factors on the tested properties for which a central composite design was applied. The significance of the contribution of individual variables was determined as well as their mutual influence. A special emphasis in the analysis of the results is on determining the correlation of the production parameters with the obtained properties of the tested samples. The conclusions are qualitative and quantitative forms, for which available software packages were used. The scientific research in this doctoral thesis has resulted in scientific contributions that can be confirmed based on the obtained results: • The influence of certain SLM parameters on changes in the structure and properties of the used Co-Cr alloy was determined. • SLM parameters were selected for the production of a dental Co-Cr alloy with improved properties compared to conventionally produced alloys. Directions for future research are also suggested.