In today's rhythm of life, while the individual is looking between stress, obligations and dissatisfaction, it is easy to consume various addictive substances into everyday life. Since all people are different in some way, each person builds a bridge over which he will cross in the hope of improvement. Polytoxicomania is a thorny bridge, but it is not impossible to cross it. Every individual strives for acceptance from the environment and seeks support in bad and good times. When he does not see a way out of his problems, he often gives up in his efforts and tends to run away from current events. The aim of this paper is to see in a certain period the occurrence of drug addiction at the Clinic for Psychiatry Clinical Hospital Rijeka depending on gender. According to pre-determined settings from the archives of the Clinic for Psychiatry CH Rijeka, the research was conducted. The obtained results showed that males enjoy different addictive substances more than females, that younger people are more prone to polytoxicomania and that the number of hospitalizations increased during the period covered by the study. The above results show that the upward trend is hospitalization due to polytoxicomania and that growth is present in both sexes. Given this phenomenon, it is important that the community recognizes it and through various actions, education and national programs to raise public awareness of the severity of this problem.