Introduction: Acute respiratory infections are the leading cause of admission of children to hospital treatment, followed by acute infectious diseases of the digestive tract. In children infected with the SARS-CoV-2 virus, there are similar symptoms from the respiratory and digestive system as in infectious diseases caused by viruses known so far. In the first wave of the pandemic, due to the large number of patients with COVID-19, valid epidemiological measures and fear of infection, there are global changes in the use of health care, which is also reflected in changes in the number of hospitalizations among both the adult population and children. Objective: To determine the impact of the Covid-19 pandemic and epidemiological measures on the total number of hospitalizations of children at the Department of Pediatrics, Karlovac General Hospital in the period from 1. 03. 2020. until 28.02.2021. compared to the pre-pandemic period of 1. 03. 2019. until 28.02.2020. years. Methods: for the purposes of the research, a retrospective analysis of medical records was conducted for a total of 863 children. Results: In the period from 1. 03. 2020. until 28.02.2021. 56.4% fewer children were admitted to the Department of Pediatrics in OB Karlovac than in the period from 1. 03. 2019. to 28.02.2020. Statistically, the number of children treated for acute respiratory (p=0.0001) and gastrointestinal infections (p=0.0001) decreased significantly. With a diagnosis of CVID-19 in the period from 01. 03. 2020. until 28.02.2021 were treated 3 children; there was no statistically significant decrease in the number of hospitalized children due to non-communicable diseases (p=0.0533). Conclusion: The closing of schools and kindergartens and the reduction of interaction between children had a significant impact on reducing the spread of acute infectious diseases of the digestive and respiratory tract, which can be used for future public health interventions to prevent seasonal viruses among children. Despite the epidemiological measures and the reduction in the capacity of the health system, there were no changes in the number of hospitalizations of children due to non-communicable diseases, which speaks in favor of the fact that parents responded in a timely manner to the health problems of their own children, putting them ahead of the fear of infection.