Diabetic foot is the most common complication of diabetes. The occurrence of this very serious and unpleasant complication is conditioned primarily by the period of time during which a person suffers from diabetes, and the methods and adequacy of its treatment. Studies show that in almost 25% of diabetic patients, a minor or major problem related to the feet will occur throughout the patient’s lifetime, while the chance of leg amputation or its part is 10 to 20 times higher with diabetes patients than with healthy people. Diabetic foot complications treatment is very time-consuming and demanding, and the final results are often not as expected. Treating diabetic foot ulcer requires hard work of all those involved in achieving the final goal, that is, healing. In addition to standard, traditional methods of treatment, such as wound healing, the use of polyurethane gels, hydrophilic dressings and the like, there has been increased talk of, but also use of, pure oxygen therapy under pressure. This method is also known as hyperbaric oxygen therapy for diabetic foot treatment. Inhalation of pure oxygen under elevated pressure results in multiplicity of increased oxygen in tissues and cells. This eliminates hypoxia, which often occurs in many pathological conditions, as a cause or consequence. By applying this type of therapy, a number of physiological mechanisms are normalized and improved. It has antibacterial effect which is of great importance in the condition of wound and tissue infections. Further research should be directed towards estimating and monitoring the true benefits of hyperbaric oxygen therapy.