Each person is an individual with their own preferences, experience and habits that can change him daily. From this point of view, the person needs to be obser ved in time and space, but also in the illness and the surrounding environment in which the person resides. People with mental illness often do not have a real insight into their illness, they are often unaware that they are ill, and so they have that same attidude towards the role and need for treatment. The aim of this research is to determine the compliance of persons suffering from mental illness. In order to obtain a better insight research is based on an examination of the patient in the form of basic as well as other diseases. Examination of the cooperation of test subjects in compliance with instructions and regularity of taking prescribed therapy from the doctors psychiatrists and other medical specialists. Test subjects were people suffering from m ental illness who is being treated at the specialist psychiatric clinic of the Health Center Pgz. 100 examinees were divided into groups depending on age, gender, degree of education, marital status, and diagnosis of the disease. The results showed that su bjects of younger age and males tend to stop taking prescribed therapy and stop ging to controled psychiatric examinations. Also, the results show that male subjects are more likely to forget to go to a checkup at another specialist's doctor, while female gender is more satisfied with the doctor's instructions. The results showed that compliance in the test subjests do not differ depending on the level of education. The above results show that it is of great importance for patients to be educated about dise ase and pharmacotherapy regardless of the disease. Also, the patient needs to get acquainted with the goals of treatment so that through this process he will follow and recognize his achievements.