Frames with masonry infill walls are composite structures which consist of frame, who can be from reinforced concrete or steel, and masonry infill which is in Croatia blocks of bricks or concrete blocks. Masonry infill significant changes the construction response to the earthquake so there is need to put it under attention. The former regulation doesn't consist explanations of how to include infill in calculations. The biggest reason is that engineers still don't understand the way that infill effects the frame. Earthquakes in the past showed that infill can have both positive and negative effects on the construction behaviour. Contemporary regulations which strive to protect the frame are usually oriented to the negative sides of the infill, that's why engineers needs to work on that topic. And the special kind of problems is masonry infill walls with the opening. Within the scope of work, it was investigated the behaviour of structure under earthquake simulation, in plane and out of plane. In that case, the nonlinear micromodel of reinforced concrete frame and masonry infill wall with the opening in the middle was modeled. The measure was 1:2,5 according to the real dimensions and for modelling was used computer programme Atena 3D Eng. For modeling the wall in computer programme it was adopted the basic properties for masonry infill from doctoral dissertation (Penava, 2012) . On that way, the parameters were established which have an effect for modelling frames with masonry and the dimensions of masonry. This thesis compare the experiment from doctoral thesis with results from Atena 3D Eng. and six simplified approaches from different researchers for constructions under earthquake. This thesis was produced in the scope of research project ''FRAme-MAsonry Composites for Modelling and Standardization (HRZZ-IP-2013-11-3013)'' from Croatian Science Foundation. The results of this thesis will be used for an insight of the influence of masonry infill walls to the reinforced concrete frames. Taking the influence of infill under consideration will bring us to the more reliable estimates of existing and new buildings.