Photocatalytic degradation of micropollutants in surface waters in a pilot reactor using solar irradiation is an innovative method used for the removal of micropollutants such as drugs, cosmetics, pesticides, and other harmful compounds that may be found in waters. In the pilot reactor, catalysts are used to promote photocatalytic reactions that lead to the degradation of micropollutants. Sunlight is used as a source of energy to activate the photocatalysts, resulting in the production of reactive oxygen species that degrade micropollutants into less harmful substances. This process can be environmentally friendly as it relies on a renewable energy source and can reduce the need for chemical compounds for water treatment. However, the success of the photocatalytic degradation of micropollutants depends on many factors, such as the type of catalyst, the intensity of solar radiation, the pH value of the water, the presence of other compounds in the water, and the duration of the process. Therefore, optimizing the reaction conditions and investigating the efficiency of the process are important aspects of research in this field. In this work, the presence of PFOS (Perfluorooctanesulfonic acid) was determined in two different locations of surface water (4 ppb) and the photocatalytic degradation of PFOS (C0=1 ppm) was investigated in a pilot reactor with different photocatalysts under natural solar radiation. Current research indicates that the use of titanium dioxide on a glass fiber mesh is the most promising method for PFOS degradation. However, in order to apply this method in real-world conditions, further research focusing on lower concentrations of PFOS is needed to assess its effectiveness and applicability.