Posttraumatic stress disorder (PTSD) is a frequent and often chronic disorder that emerges after one experienced or witnessed a life-threatening event and can be civil or war. The participants to this survey were the veterans who fought in the Homeland war and the people without any war experience. One group of veterans had the PTSD, while the other group of veterans did not develop PTSD or other psychological disorders. The psychiatric disorders were diagnosed by the International Neuropsychiatric Interview (MINI) in Croatian language. The Clinician Administered PTSD Scale was used on the veterans with a diagnosis of PTSD, too. The quality of life questionnaire WHOQOL-BREF was filled in by all the participants and the information about the physical illnesses, accompanied by the medical documentation, was collected. The veterans with or without PTSD and the people without any war experience did not differ in age or marital status, but the people who didn't participate in the war had significantly better education. It has been determined that the veterans with the PTSD had significantly lower quality of life in every domain compared with the veterans without the PTSD and the participants without any war experience. The 40% of veterans who had developed PTSD had other psychiatric comorbidities, as psychotic PTSD, depression, anxiety disorders and had more physical comorbidities than veterans who had not developed PTSD. The most common physical illnesses that the people with the PTSD experience are locomotor, cardiovascular, endocrine and gastrointestinal. The psychiatric and physical comorbidity among veterans with the PDSD lowers significantly all aspects of the quality of life. The severity of symptoms of the PTSD is not significantly related to the domains of the quality of life, but the length of the therapy is significantly connected to the symptoms of avoidance and numbing within the clinical features of the PTSD, meaning that the veterans with those symptoms have a longer therapy. To the best of our knowledge this is the first research of the connection of the quality of life of the people with the PTSD who have both psychiatric and physical comorbidity in Croatia, and according to the accessible literature, in the world, too.