The aim of this study was to determine differences in the perceived stress between participants engaged in yoga, participants engaged in sport activities and participants that are not engaged in any kind of physical activity. In addition, we wanted to examine the mediation influence of a mindfulness meditation on the relationship between practicing yoga and perceived stress. A total of 441 female participants fulfilled the Perceived Stress Scale (Cohen, Kamarck and Mermelstein, 1983) and Mindfulness Attention Awareness Scale (Brown and Ryan, 2009). The results of the variance analysis showed that there is a statistically significant difference in perceived stress among practitioners of yoga and participants that are not involved in any kind of physical activity. However, the difference between the participants involved in yoga and the participants involved in sport activities wasn't statistically significant. We were not able to determine mediation influence of mindfulness meditation due to the absence of significant correlation between practicing yoga and mindfulness meditation.