There is a growing body of research suggesting that observing and helping those who suffer results in both compassion fatigue and compassion satisfaction. Together they form the construct called professional quality of life (ProQOL). The goal of this research is to determine the levels of compassion fatigue (burnout and secondary traumatic stress) and compassion satisfaction among nurses; to explore their relationship with social support, negative emotionality, and self-compassion. The role of each variable in predicting the outcomes of professional quality of life was also assessed. 250 registered nurses filled out the online version of the form. The form consisted of the following questionnaires: Scale of Social Support at Work and in the Family (Šimunić, Gregov and Prorokov, 2016), ProQOL-5 (Stamm, 2010), Self-compassion scale (Neff, 2003) and the subscale of Negative Emotionality from the BFI-2 Questionnaire (Soto and John, 2017). All three ProQOL domains were present in moderation. After running three hierarchical regression analyses, it was concluded that higher negative emotionality and age can successfully predict higher levels of STS. Negative emotionality, lower social support, lower selfcompassion, and lower compassion satisfaction were significantly related to higher levels of burnout. After testing for their predictive power, they proved to have a significant role in explaining burnout levels. Similarly, negative emotionality and lower social support from their superiors and family were also shown to be significant factors in predicting the levels of compassion satisfaction, while self-compassion proved to be a mediator of the relationship between negative emotionality and compassion satisfaction.