Muscle hypertrophy is a complex physiological process that plays a vital role in muscle mass development and increasing repetitive strength. This paper explores the factors, mechanisms, and practical applications of hypertrophy, with a particular emphasis on training, nutrition and recovery. Given the significant role of muscle hypertrophy in sports performance, rehabilitation, and overall health, understanding this process is crucial for athletes, coaches, recreational enthusiasts, and healthcare professionals. This review paper is based on a systematic review of the literature, and the database has been published. Papers published in the last 7 years were included, and from a total of 704 papers collected by searching the term "skeletal muscle hypertrophy", 31 relevant ones were selected. Selection criteria were meta-analyses, randomized controlled trials, review papers and systematic reviews that studied changes in muscle or lean mass or factors of muscle damage in untrained and trained individuals regardless of gender and age. These factors include training types, intensity, volume, nutrition and genetic predispositions. The results of relevant research that dealt with these aspects were also analyzed. The results of this literature review showed that a larger volume of training with a choice of exercises that are performed in the full range of motion through an elongated muscle position gives the best results in terms of increasing muscle mass. In addition, caloric surplus, sufficient protein intake and quality recovery additionally help to speed up the process of muscle hypertrophy. Given the complexity of muscle hypertrophy, further research is warranted to better understand the mechanisms and factors influencing this process. Considering individual differences and an individualized approach may be the key to achieving optimal results in muscle hypertrophy.