The very origins of the observations of the architectural proportions of human anatomy, and taking interest in developing the symmetry, as well as the muscular strength and endurance of the human body can be traced back to the 19th century. Since then, there is a growing preference and desire to achieve greater mucle definition. Eventually, the term 'Bodybuilding' has been introduced and came to refer to the systematic development, definition of muscles and the development of muscular symmetry and proportion. Bodybuilding is one of the most efficient ways to build muscle. We can say it is an all-day activity, because bodybuilding is not just hard training; it also requires a healthy nutrition and rest. In bodybuilding, as in other sports and physical activities, particular attention must be given to sexual dimorphism, i.e., the difference in the physiology and morphology between men and women, as well as in the body fat percentage and their endocrine system in order to be able to adjust their diet and the workout intensity to achieve their fitness goals. This paper focuses on defining bodybuilding as a sport, an aesthetic activity and a lifestyle. The research will elaborate on the close connection between nutrition and bodybuilding, i.e., their interdependence, as well as both the positive and negative effects of nutrition on musle mass during bodybuilding. A balanced diet rich in nutrients, such as proteins, carbohydrates, vitamins and minerals, with an intake of supplements is a crucial factor for building up muscle mass and reducing body fat, while adjusting the workout dynamics and intensity to fit one's sex, age and the overall mental and physical condition will enable the person to achieve a strong, harmoniuos and aesthetically appealing body and prevent potential diseases and injuries.