prikaz prve stranice dokumenta Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis
  Preuzmi
PDF 1.4 MB
Znanstveni rad - Izvorni znanstveni rad
Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis
Clinical and Developmental Immunology, 213 (2013); 750406. https://doi.org/10.1155/2013/750406
Grubić Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Milin, Čedomila; Radošević-Stašić, Biserka

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Grubić Kezele, T., Blagojević Zagorac, G., Jakovac, H., Domitrović, R., Milin, Č. i Radošević Stašić, B. (2013). Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology, 213.. doi: 10.1155/2013/750406

Grubić Kezele, Tanja, et al. "Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis." Clinical and Developmental Immunology, vol. 213, 2013. https://doi.org/10.1155/2013/750406

Grubić Kezele, Tanja, Gordana Blagojević Zagorac, Hrvoje Jakovac, Robert Domitrović, Čedomila Milin i Biserka Radošević Stašić. "Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis." Clinical and Developmental Immunology 213 (2013). https://doi.org/10.1155/2013/750406

Grubić Kezele, T., et al. (2013) 'Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis', Clinical and Developmental Immunology, 213. doi: 10.1155/2013/750406

Grubić Kezele T, Blagojević Zagorac G, Jakovac H, Domitrović R, Milin Č, Radošević Stašić B. Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology [Internet]. 2013. [pristupljeno 25.12.2024.];213. doi: 10.1155/2013/750406

T. Grubić Kezele, G. Blagojević Zagorac, H. Jakovac, R. Domitrović, Č. Milin i B. Radošević Stašić, "Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis", Clinical and Developmental Immunology, vol. 213, 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:075264. [Citirano: 25.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:075264
Podaci o radu
Naslov (engleski)Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis
AutorTanja Grubić Kezele
AutorGordana Blagojević Zagorac
AutorHrvoje Jakovac
AutorRobert Domitrović
AutorČedomila Milin
AutorBiserka Radošević-Stašić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Sažetak (engleski)
In a search of peripheral factors that could be responsible for the discrepancy in susceptibility to EAE in Albino Oxford (AO) and Dark Agouti (DA) rats, we estimated the expression of metallothioneins I/II (MT), heat shock protein-gp96, interleukin (IL)- 6, and transforming growth factor (TGF)-𝛽 in the livers of these animals. Rats were immunized with bovine brain homogenate (BBH) emulsified in complete Freund adjuvant (CFA) or only with CFA. Western blot and immunohistochemical analyses were done on day 12 after the immunization, as well as in intact rats.The data have shown that during the first attack of EAE only the EAE prone-DA rats markedly upregulated the hepatic MTs, gp96, IL-6, and TGF-𝛽. In contrast, AO rats had a significantly higher expression of MT I/II, IL-6, and TGF-𝛽 in intact liver (𝑃 < 0, 001), suggesting that the greater constitutive expression of these proteins contributed to the resistance of EAE. Besides, since previously we found that AO rats reacted on immunization by an early upregulation of TGF-𝛽 on several hepatic structures (vascular endothelium, Kupffer cells, and hepatocytes), the data suggest that the specific hepatic microenvironment might contribute also to the faster recovery of these rats from EAE.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical and Developmental Immunology
Brojčani podacivol. 213, 750406
e-ISSN1740-2530
DOIhttps://doi.org/10.1155/2013/750406
URN:NBNurn:nbn:hr:184:075264
Datum objave publikacije2013
URL dokumentaes http://dx.doi.org/10.1155/2013/750406
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-09-13 15:32:37