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The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage
Molecular and Cellular Proteomics, (2017); https://doi.org/10.1074/mcp.RA117.000160
Fabrik, Ivo; ...; ...; ...; ...; ...; ...; ...; ...; ...; Šantić, Marina; ...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Fabrik, I. i Šantić, M. (2017). The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage. Molecular and Cellular Proteomics. doi: 10.1074/mcp.RA117.000160

Fabrik, Ivo i Marina Šantić. "The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage." Molecular and Cellular Proteomics, 2017. https://doi.org/10.1074/mcp.RA117.000160

Fabrik, Ivo i Marina Šantić. "The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage." Molecular and Cellular Proteomics (2017). https://doi.org/10.1074/mcp.RA117.000160

Fabrik, I. i Šantić, M. (2017) 'The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage', Molecular and Cellular Proteomics. doi: 10.1074/mcp.RA117.000160

Fabrik I, Šantić M. The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage. Molecular and Cellular Proteomics [Internet]. 18.10.2017. [pristupljeno 16.05.2024.]. doi: 10.1074/mcp.RA117.000160

I. Fabrik i M. Šantić, "The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage", Molecular and Cellular Proteomics, Listopad 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:793379. [Citirano: 16.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:793379
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Naslov (engleski)The early dendritic cell signaling induced by virulent Francisella tularensis strain occurs in phases and involves the activation of ERKs and p38 in the later stage
AutorIvo Fabrik
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AutorMarina Šantić
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Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Dendritic cells (DCs) infected by Francisella tularensis are poorly activated and do not undergo classical maturation process. While reasons of such unresponsiveness are not fully understood, their impact on the priming of immunity is well appreciated. Previous attempts to explain the behavior of Francisella-infected DCs were hypothesis-driven and focused on events at later stages of infection. Here, we took an alternative unbiased approach by applying methods of global phosphoproteomics to analyze the dynamics of cell signaling in primary DCs during the first hour of infection by Francisella tularensis. Presented results show that the early response of DCs to Francisella occurs in phases and that ERK and p38 signaling modules induced at the later stage are differentially regulated by virulent and attenuated ΔdsbA strain. These findings imply that the temporal orchestration of host pro-inflammatory pathways represents the integral part of Francisella life-cycle inside hijacked DCs.
Ključne riječi (hrvatski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objavePrihvaćen za objavljivanje
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecular and Cellular Proteomics
p-ISSN1535-9476
e-ISSN1535-9484
DOIhttps://doi.org/10.1074/mcp.RA117.000160
URN:NBNurn:nbn:hr:184:793379
Datum objave publikacije2017-10-18
URL dokumentahttp://www.mcponline.org/content/early/2017/10/18/mcp.RA117.000160.long
URL dokumentahttps://www.ncbi.nlm.nih.gov/pubmed/29046388
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-10-23 21:02:18