prikaz prve stranice dokumenta The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells
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The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells
European Journal of Immunology, 43 (2013); 2151-2161. https://doi.org/10.1002/eji.201343433
Lankry, Dikla; Lenac Roviš, Tihana; Jonjić, Stipan; Mandelboim, Ofer

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Lankry, D., Lenac Roviš, T., Jonjić, S. i Mandelboim, O. (2013). The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells. European Journal of Immunology, 43., 2151-2161. doi: 10.1002/eji.201343433

Lankry, Dikla, et al. "The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells." European Journal of Immunology, vol. 43, 2013, str. 2151-2161. https://doi.org/10.1002/eji.201343433

Lankry, Dikla, Tihana Lenac Roviš, Stipan Jonjić i Ofer Mandelboim. "The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells." European Journal of Immunology 43 (2013): 2151-2161. https://doi.org/10.1002/eji.201343433

Lankry, D., et al. (2013) 'The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells', European Journal of Immunology, 43, str. 2151-2161. doi: 10.1002/eji.201343433

Lankry D, Lenac Roviš T, Jonjić S, Mandelboim O. The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells. European Journal of Immunology [Internet]. 2013. [pristupljeno 12.05.2024.];43:2151-2161. doi: 10.1002/eji.201343433

D. Lankry, T. Lenac Roviš, S. Jonjić i O. Mandelboim, "The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells", European Journal of Immunology, vol. 43, str. 2151-2161, 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:420865. [Citirano: 12.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:420865
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Naslov (engleski)The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells
AutorDikla Lankry
AutorTihana Lenac Roviš
AutorStipan Jonjić
AutorOfer Mandelboim
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The activity of NK cells is controlled by inhibitory and activating receptors. The inhibitory receptors interact mostly with MHC class I proteins, however, inhibitory receptors such as CD300a, which bind to non‐MHC class I ligands, also exist. Recently, it was discovered that phosphatidylserine (PS) is a ligand for CD300a and that the interaction between PS expressed on apoptotic cells and CD300a inhibits the uptake of apoptotic cells by phagocytic cells. Whether PS can inhibit NK‐cell activity through CD300a is unknown. Here, we have generated specific antibodies directed against CD300a and we used these mAbs to demonstrate that various NK‐cell clones express different levels of CD300a. We further demonstrated that both CD300a and its highly homologous molecule CD300c bind to the tumor cells equally well and that they recognize PS and additional unknown ligand(s) expressed by tumor cells. Finally, we showed that blocking the PS–CD300a interaction resulted in increased NK‐cell killing of tumor cells. Collectively, we demonstrate a new tumor immune evasion mechanism that is mediated through the interaction between PS and CD300a and we suggest that CD300c, similarly to CD300a, also interacts with PS.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Immunology
Brojčani podacivol. 43, str. 2151-2161
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201343433
URN:NBNurn:nbn:hr:184:420865
Datum objave publikacije2013
URL dokumentahttps://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201343433
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-10-14 18:03:01