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ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma
European Journal of Immunology, 41 (2011), 7; 1902-1912. https://doi.org/10.1002/eji.201141417
Jovanović, Ivan; Radosavljević, Gordana; Mitrović, Maja; Juranić Lisnić, Vanda; McKenzie, Andrew; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Jovanović, I., Radosavljević, G., Mitrović, M., Juranić Lisnić, V., McKenzie, A., Arsenijević, N. ... Lukić, M. (2011). ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma. European Journal of Immunology, 41. (7), 1902-1912. doi: 10.1002/eji.201141417

Jovanović, Ivan, et al. "ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma." European Journal of Immunology, vol. 41, br. 7, 2011, str. 1902-1912. https://doi.org/10.1002/eji.201141417

Jovanović, Ivan, Gordana Radosavljević, Maja Mitrović, Vanda Juranić Lisnić, Andrew McKenzie, Nebojša Arsenijević, Stipan Jonjić i Miodrag Lukić. "ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma." European Journal of Immunology 41, br. 7 (2011): 1902-1912. https://doi.org/10.1002/eji.201141417

Jovanović, I., et al. (2011) 'ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma', European Journal of Immunology, 41(7), str. 1902-1912. doi: 10.1002/eji.201141417

Jovanović I, Radosavljević G, Mitrović M, Juranić Lisnić V, McKenzie A, Arsenijević N, i sur.. ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma. European Journal of Immunology [Internet]. 2011. [pristupljeno 15.05.2024.];41(7):1902-1912. doi: 10.1002/eji.201141417

I. Jovanović, et al., "ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma", European Journal of Immunology, vol. 41, br. 7, str. 1902-1912, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:883531. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:883531
Podaci o radu
Naslov (engleski)ST2 Deletion Enhances Innate and Acquired Immunity to Murine Mammary Carcinoma
AutorIvan Jovanović
AutorGordana Radosavljević
AutorMaja Mitrović
AutorVanda Juranić Lisnić
MBZ: 296602
AutorAndrew McKenzie
AutorNebojša Arsenijević
AutorStipan Jonjić
AutorMiodrag Lukić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
ST2 is a member of the IL-1 receptor family and IL-33 was recently identified as its natural ligand. The IL-33/ST2 pathway regulates Th1/Th2 immune responses in autoimmune and inflammatory conditions, but the role of ST2 signaling in tumor growth and metastasis has not been investigated. We aimed to investigate whether ST2 gene deletion affects tumor appearance, growth, and metastasis, and antitumor immunity in an experimental metastatic breast cancer model. Deletion of ST2 in BALB/c mice bearing mammary carcinoma attenuated tumor growth and metastasis, which was accompanied by increased serum levels of IL-17, IFN-γ, and TNF-α and decreased IL-4. Tumor-bearing ST2−/− mice had significantly higher percentages of activated CD27highCD11bhigh NK cells, CD69+ and KLRG− NK cells and higher cytotoxic activity of splenocytes, NK cells, and CD8+ T cells in vitro. A significantly higher number of NK cells expressing IFN-γ were found in ST2−/− mice compared with WT recipients. In vivo depletion of CD8+ or NK cells revealed a key role for NK cells in enhanced antitumor immunity in ST2−/− mice. We report for the first time that suppressed breast cancer progression and metastasis in mice lacking ST2 corresponds mainly with enhanced cytotoxic activity of NK cells, and increased systemic Th1/Th17 cytokines.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Immunology
Brojčani podacivol. 41, br. 7, str. 1902-1912
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201141417
URN:NBNurn:nbn:hr:184:883531
Datum objave publikacije2011
URL dokumentahttp://bib.irb.hr/517771
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-10-15 06:07:45