Coagulation or blood clotting is a clotting process that stops bleeding from the blood vessels and is one of the hemostasis processes. The aim of this study was to determine the disorders of coagulation parameters in patients with multiple body injuries treated in the Intensive Care Unit of the Anesthesiology Clinic and the intensive treatment of the Rijeka Clinical Hospital Center. A further aim is to determine whether there is a correlation between the coagulation parameters and the outcomes of the patient. Respondents and Methods In this study, data will be analyzed for patients with multiple body injuries treated in the Intensive Care Unit of the Anesthesiology Clinic and intensive treatment of the Rijeka Clinical Hospital Center in the period from January 1, 2016 to January 1, 2017. For the purpose of data collection, the archives of the Clinic for anesthesiology and intensive care will be used. From the medical documentation, the following data will be analyzed: demographic characteristics, diagnosis, operation, duration of treatment in the intensive care unit, outcome of the operation, amount of blood / blood preparations, coagulation parameters. Risk factors for the development of coagulation disorders in traumatized patients will also be established and analyzed. When compiling and processing data ethical principles will be respected. Results In the Intensive Care Unit of the Anesthesiology and Intensive Care Clinic in the period from 1 January 2016 to 1 January 2017, 124 patients with multiple body injuries were treated. The results of the study indicate the apparent changes in coagulation parameters in the form of elevated mean values of fibrinogen, decreased antithrombin III value, APTV prolongation, and shortened prothrombin time. The mean acid-status analysis shows the presence of metabolic acidosis. Conclusion The observed changes in coagulation parameters indicate coagulopathy in patients with multiple bodily injuries.