prikaz prve stranice dokumenta Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
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Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
Proceedings of the National Academy of Sciences, 110 (2013), 41; 16550-16555. https://doi.org/10.1073/pnas.1310215110
Tršan, Tihana; Busche, Andreas; Abram, Maja; Wensveen, F. M.; Lemmermann, N. A.; Arapović, Maja; Babić, Marina; Tomić, Adriana; Golemac, Mijo; Brinkmann, Melanie M.; Jager, W.; Oxenius, A.; Polić, Bojan; Krmpotić, Astrid; Messerle, M.; Jonjić, Stipan Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Tršan, T., Busche, A., Abram, M., Wensveen, F. M., Lemmermann, N. A., Arapović, M. ... Jonjić, S. (2013). Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 . Proceedings of the National Academy of Sciences, 110. (41), 16550-16555. doi: 10.1073/pnas.1310215110

Tršan, Tihana, et al. "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ." Proceedings of the National Academy of Sciences, vol. 110, br. 41, 2013, str. 16550-16555. https://doi.org/10.1073/pnas.1310215110

Tršan, Tihana, Andreas Busche, Maja Abram, F. M. Wensveen, N. A. Lemmermann, Maja Arapović, Marina Babić, et al. "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ." Proceedings of the National Academy of Sciences 110, br. 41 (2013): 16550-16555. https://doi.org/10.1073/pnas.1310215110

Tršan, T., et al. (2013) 'Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ', Proceedings of the National Academy of Sciences, 110(41), str. 16550-16555. doi: 10.1073/pnas.1310215110

Tršan T, Busche A, Abram M, Wensveen FM, Lemmermann NA, Arapović M, i sur.. Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 . Proceedings of the National Academy of Sciences [Internet]. 19.09.2013. [pristupljeno 08.11.2024.];110(41):16550-16555. doi: 10.1073/pnas.1310215110

T. Tršan, et al., "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ", Proceedings of the National Academy of Sciences, vol. 110, br. 41, str. 16550-16555, Rujan 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:913348. [Citirano: 08.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:913348
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Naslov (engleski)Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
AutorTihana Tršan
AutorAndreas Busche
AutorMaja Abram
AutorF. M. Wensveen
AutorN. A. Lemmermann
AutorMaja Arapović
AutorMarina Babić
AutorAdriana Tomić
AutorMijo Golemac
AutorMelanie M. Brinkmann
AutorW. Jager
AutorA. Oxenius
AutorBojan Polić
AutorAstrid Krmpotić
AutorM. Messerle
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically relevant infections and tumors. NKG2D is one of the most important activating NK cell receptors that plays a role in costimulation of CD8 T cells. Here we demonstrate that the expression of CD8 T-cell epitope of Listeria monocytogenes by a recombinant mouse CMV (MCMV) expressing the NKG2D ligand retinoic acid early-inducible protein 1-gamma (RAE-1γ) dramatically enhanced the effectiveness and longevity of epitope-specific CD8 T-cell response and conferred protection against a subsequent challenge infection with Listeria monocytogenes. Unexpectedly, theattenuatedgrowth in vivo of the CMV vector expressing RAE-1γ and its capacity to enhance specific CD8 T-cell response were preserved even in mice lacking NKG2D, implying additional immune function for RAE-1γ beyond engagement of NKG2D. Thus, vectors expressing RAE-1γ represent a promising approach in the development of CD8 T-cell– based vaccines
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProceedings of the National Academy of Sciences
Brojčani podacivol. 110, br. 41, str. 16550-16555
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.1310215110
URN:NBNurn:nbn:hr:184:913348
Datum objave publikacije2013-09-19
Datum objave publikacije2013-10-08
ProjektŠifra: 322693
Naziv (engleski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttp://www.pnas.org/cgi/doi/10.1073/pnas.1310215110
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-22 22:42:42