prikaz prve stranice dokumenta NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice
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NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice
European Journal of Immunology, 47 (2017), 7; 1123-1135. https://doi.org/10.1002/eji.201646805
Kavazović, Inga; Lenartić, Maja; Jelenčić, Vedrana; Jurković, Slaven; Lemmermann, Niels A.W.; Jonjić, Stipan; Polić, Bojan; Wensveen, Felix M.

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Kavazović, I., Lenartić, M., Jelenčić, V., Jurković, S., Lemmermann, N. A., Jonjić, S. ... Wensveen, F. M. (2017). NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice. European Journal of Immunology, 47. (7), 1123-1135. doi: 10.1002/eji.201646805

Kavazović, Inga, et al. "NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice." European Journal of Immunology, vol. 47, br. 7, 2017, str. 1123-1135. https://doi.org/10.1002/eji.201646805

Kavazović, Inga, Maja Lenartić, Vedrana Jelenčić, Slaven Jurković, Niels A.W. Lemmermann, Stipan Jonjić, Bojan Polić i Felix M. Wensveen. "NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice." European Journal of Immunology 47, br. 7 (2017): 1123-1135. https://doi.org/10.1002/eji.201646805

Kavazović, I., et al. (2017) 'NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice', European Journal of Immunology, 47(7), str. 1123-1135. doi: 10.1002/eji.201646805

Kavazović I, Lenartić M, Jelenčić V, Jurković S, Lemmermann NA, Jonjić S, i sur.. NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice. European Journal of Immunology [Internet]. 07.2017. [pristupljeno 24.12.2024.];47(7):1123-1135. doi: 10.1002/eji.201646805

I. Kavazović, et al., "NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice", European Journal of Immunology, vol. 47, br. 7, str. 1123-1135, Srpanj 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:922259. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:922259
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Naslov (engleski)NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice
AutorInga Kavazović
AutorMaja Lenartić
AutorVedrana Jelenčić
AutorSlaven Jurković
AutorNiels A.W. Lemmermann
AutorStipan Jonjić
AutorBojan Polić
AutorFelix M. Wensveen
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Natural killer group 2 member D (NKG2D) is an activating receptor that is expressed on most cytotoxic cells of the immune system, including NK cells, γδ, and CD8+ T cells. It is still a matter of debate whether and how NKG2D mediates priming of CD8+ T cells in vivo, due to a lack of studies where NKG2D is eliminated exclusively in these cells. Here, we studied the impact of NKG2D on effector CD8+ T-cell formation. NKG2D deficiency that is restricted to murine CD8+ T cells did not impair antigen-specific T-cell expansion following mouse CMV and lymphocytic choriomeningitis virus infection, but reduced their capacity to produce cytokines. Upon infection, conventional dendritic cells induce NKG2D ligands, which drive cytokine production on CD8+ T cells via the Dap10 signaling pathway. T-cell development, homing, and proliferation were not affected by NKG2D deficiency and cytotoxicity was only impaired when strong T-cell receptor (TCR) stimuli were used. Transfer of antigen-specific CD8+ T cells demonstrated that NKG2D deficiency attenuated their capacity to reduce viral loads. The inability of NKG2D-deficient cells to produce cytokines could be overcome with injection of IL-15 superagonist during priming. In summary, our data show that NKG2D has a nonredundant role in priming of CD8+ T cells to produce antiviral cytokines.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Immunology
Brojčani podacivol. 47, br. 7, str. 1123-1135
p-ISSN0014-2980
DOIhttps://doi.org/10.1002/eji.201646805
URN:NBNurn:nbn:hr:184:922259
Datum objave publikacije2017-07
Datum objave publikacije2017-05-02
ProjektŠifra: 274995
Naziv (hrvatski): Memory Control; The role of NKG2D and the T-cell receptor in memory T cell biology.
Kratica: NKG2D IN T-CELLS
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttp://doi.wiley.com/10.1002/eji.201646805
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-11-30 08:02:40