prikaz prve stranice dokumenta Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1
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Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1
Cell Reports, 26 (2019), 9; 2394-2406.e5. https://doi.org/10.1016/j.celrep.2019.02.017
Gawish, Riem; Bulat, Tanja; Biaggio, Mario; Lassnig, Caroline; Bago-Horvath, Zsuzsanna; Macho-Maschler, Sabine; Poelzl, Andrea; Simonović, Natalija; Prchal-Murphy, Michaela; Rom, Rita; Amenitsch, Lena; Ferrarese, Luca; Kornhoff, Juliana; Lederer, Therese; Svinka, Jasmin; Eferl, Robert; Bosmann, Markus; Kalinke, Ulrich; Stoiber, Dagmar; Sexl, Veronika; Krmpotić, Astrid; Jonjić, Stipan; Müller, Mathias; Strobl, Birgit Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Gawish, R., Bulat, T., Biaggio, M., Lassnig, C., Bago Horvath, Z., Macho Maschler, S. ... Strobl, B. (2019). Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Reports, 26. (9), 2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017

Gawish, Riem, et al. "Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1." Cell Reports, vol. 26, br. 9, 2019, str. 2394-2406.e5. https://doi.org/10.1016/j.celrep.2019.02.017

Gawish, Riem, Tanja Bulat, Mario Biaggio, Caroline Lassnig, Zsuzsanna Bago Horvath, Sabine Macho Maschler, Andrea Poelzl, et al. "Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1." Cell Reports 26, br. 9 (2019): 2394-2406.e5. https://doi.org/10.1016/j.celrep.2019.02.017

Gawish, R., et al. (2019) 'Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1', Cell Reports, 26(9), str. 2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017

Gawish R, Bulat T, Biaggio M, Lassnig C, Bago Horvath Z, Macho Maschler S, i sur.. Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Reports [Internet]. 02.2019. [pristupljeno 23.11.2024.];26(9):2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017

R. Gawish, et al., "Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1", Cell Reports, vol. 26, br. 9, str. 2394-2406.e5, Veljača 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:558534. [Citirano: 23.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:558534
Podaci o radu
Naslov (engleski)Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1
AutorRiem Gawish
AutorTanja Bulat
AutorMario Biaggio
AutorCaroline Lassnig
AutorZsuzsanna Bago-Horvath
AutorSabine Macho-Maschler
AutorAndrea Poelzl
AutorNatalija Simonović
AutorMichaela Prchal-Murphy
AutorRita Rom
AutorLena Amenitsch
AutorLuca Ferrarese
AutorJuliana Kornhoff
AutorTherese Lederer
AutorJasmin Svinka
AutorRobert Eferl
AutorMarkus Bosmann
AutorUlrich Kalinke
AutorDagmar Stoiber
AutorVeronika Sexl
AutorAstrid Krmpotić
AutorStipan Jonjić
AutorMathias Müller
AutorBirgit Strobl
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Cytomegalovirus (CMV) has a high prevalence worldwide, is often fatal for immunocompromised patients, and causes bone marrow suppression. Deficiency of signal transducer and activator of transcription 1 (STAT1) results in severely impaired antiviral immunity. We have used cell-type restricted deletion of Stat1 to determine the importance of myeloid cell activity for the defense against murine CMV (MCMV). We show that myeloid STAT1 limits MCMV burden and infection-associated pathology in the spleen but does not affect ultimate clearance of infection. Unexpectedly, we found an essential role of myeloid STAT1 in the induction of extramedullary hematopoiesis (EMH). The EMH-promoting function of STAT1 was not restricted to MCMV infection but was also observed during CpG oligodeoxynucleotide-induced sterile inflammation. Collectively, we provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCell Reports
Brojčani podacivol. 26, br. 9, str. 2394-2406.e5
p-ISSN2211-1247
DOIhttps://doi.org/10.1016/j.celrep.2019.02.017
URN:NBNurn:nbn:hr:184:558534
Datum objave publikacije2019-02
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S2211124719301792
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2019-03-05 20:35:27