prikaz prve stranice dokumenta NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection
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NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection
PLOS Pathogens, 15 (2019), 4; e1007725. https://doi.org/10.1371/journal.ppat.1007725
Pallmer, Katharina; Barnstorf, Isabel; Baumann, Nicolas S.; Borsa, Mariana; Jonjić, Stipan; Oxenius, Annette

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Pallmer, K., Barnstorf, I., Baumann, N. S., Borsa, M., Jonjić, S. i Oxenius, A. (2019). NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection. PLOS Pathogens, 15. (4). doi: 10.1371/journal.ppat.1007725

Pallmer, Katharina, et al. "NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection." PLOS Pathogens, vol. 15, br. 4, 2019. https://doi.org/10.1371/journal.ppat.1007725

Pallmer, Katharina, Isabel Barnstorf, Nicolas S. Baumann, Mariana Borsa, Stipan Jonjić i Annette Oxenius. "NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection." PLOS Pathogens 15, br. 4 (2019). https://doi.org/10.1371/journal.ppat.1007725

Pallmer, K., et al. (2019) 'NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection', PLOS Pathogens, 15(4). doi: 10.1371/journal.ppat.1007725

Pallmer K, Barnstorf I, Baumann NS, Borsa M, Jonjić S, Oxenius A. NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection. PLOS Pathogens [Internet]. 17.04.2019. [pristupljeno 24.12.2024.];15(4). doi: 10.1371/journal.ppat.1007725

K. Pallmer, I. Barnstorf, N. S. Baumann, M. Borsa, S. Jonjić i A. Oxenius, "NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection", PLOS Pathogens, vol. 15, br. 4, Travanj 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:738160. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:738160
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Naslov (engleski)NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection
AutorKatharina Pallmer
AutorIsabel Barnstorf
AutorNicolas S. Baumann
AutorMariana Borsa
AutorStipan Jonjić
AutorAnnette Oxenius
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Besides their function in recognizing cancerous and virally infected cells, natural killer (NK) cells have the potential to shape adaptive immune responses. However, the mechanisms employed by NK cells to negatively regulate virus-specific CD8 T cell responses remain to be fully defined. Using activating receptor natural cytotoxicity receptor (NCR) 1 deficient (NCR1gfp/gfp) mice, we found increased numbers of virus-specific CD8 T cells, leading to enhanced virus control during acute LCMV infection. Furthermore, virus-specific CD8 T cells were more activated in the absence of NCR1, resulting in exacerbated immunopathology, documented by weight loss, and superior virus control early during chronic LCMV infection. Transfer experiments of virus-specific CD8 T cells into NCR1 deficient hosts revealed a direct cross talk between NK and CD8 T cells. Studies on the splenic microarchitecture revealed pronounced disorganization of T cells in infected NCR1gfp/gfp mice, resulting in enhanced immunopathology and disruption of the T cell niche upon chronic LCMV infection. Our data show a novel pathway employed by NK cells to regulate antiviral CD8 T cell responses, namely direct recognition and elimination of activated CD8 T cells via NCR1 early during infection to protect the host from an overshooting T cell response.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLOS Pathogens
Brojčani podacivol. 15, br. 4, e1007725
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1007725
URN:NBNurn:nbn:hr:184:738160
Datum objave publikacije2019-04-17
URL dokumentahttp://dx.plos.org/10.1371/journal.ppat.1007725
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-04-24 18:44:35