prikaz prve stranice dokumenta Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge
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Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge
PLOS Pathogens, 15 (2019), 9; e1008036. https://doi.org/10.1371/journal.ppat.1008036
Zheng, Xiaoyan; Oduro, Jennifer D.; Boehme, Julia D.; Borkner, Lisa; Ebensen, Thomas; Heise, Ulrike; Gereke, Marcus; Pils, Marina C.; Krmpotic, Astrid; Guzmán, Carlos A.; Bruder, Dunja; Čičin-Šain, Luka

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Zheng, X., Oduro, J. D., Boehme, J. D., Borkner, L., Ebensen, T., Heise, U. ... Čičin Šain, L. (2019). Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge. PLOS Pathogens, 15. (9). doi: 10.1371/journal.ppat.1008036

Zheng, Xiaoyan, et al. "Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge." PLOS Pathogens, vol. 15, br. 9, 2019. https://doi.org/10.1371/journal.ppat.1008036

Zheng, Xiaoyan, Jennifer D. Oduro, Julia D. Boehme, Lisa Borkner, Thomas Ebensen, Ulrike Heise, Marcus Gereke, et al. "Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge." PLOS Pathogens 15, br. 9 (2019). https://doi.org/10.1371/journal.ppat.1008036

Zheng, X., et al. (2019) 'Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge', PLOS Pathogens, 15(9). doi: 10.1371/journal.ppat.1008036

Zheng X, Oduro JD, Boehme JD, Borkner L, Ebensen T, Heise U, i sur.. Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge. PLOS Pathogens [Internet]. 16.09.2019. [pristupljeno 02.12.2024.];15(9). doi: 10.1371/journal.ppat.1008036

X. Zheng, et al., "Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge", PLOS Pathogens, vol. 15, br. 9, Rujan 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:304219. [Citirano: 02.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:304219
Podaci o radu
Naslov (engleski)Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge
AutorXiaoyan Zheng
AutorJennifer D. Oduro
AutorJulia D. Boehme
AutorLisa Borkner
AutorThomas Ebensen
AutorUlrike Heise
AutorMarcus Gereke
AutorMarina C. Pils
AutorAstrid Krmpotic
AutorCarlos A. Guzmán
AutorDunja Bruder
AutorLuka Čičin-Šain
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes life-long latent infection in a high percentage of the population worldwide. CMV induces the strongest and most durable CD8+ T cell response known in human clinical medicine. Due to its unique properties, the virus represents a promising candidate vaccine vector for the induction of persistent cellular immunity. To take advantage of this, we constructed a recombinant murine CMV (MCMV) expressing an MHC-I restricted epitope from influenza A virus (IAV) H1N1 within the immediate early 2 (ie2) gene. Only mice that were immunized intranasally (i.n.) were capable of controlling IAV infection, despite the greater potency of the intraperitoneally (i.p.) vaccination in inducing a systemic IAV-specific CD8+ T cell response. The protective capacity of the i.n. immunization was associated with its ability to induce IAV-specific tissue-resident memory CD8+ T (CD8TRM) cells in the lungs. Our data demonstrate that the protective effect exerted by the i.n. immunization was critically mediated by antigen-specific CD8+ T cells. CD8TRM cells promoted the induction of IFNγ and chemokines that facilitate the recruitment of antigen-specific CD8+ T cells to the lungs. Overall, our results showed that locally applied MCMV vectors could induce mucosal immunity at sites of entry, providing superior immune protection against respiratory infections.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLOS Pathogens
Brojčani podacivol. 15, br. 9, e1008036
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1008036
URN:NBNurn:nbn:hr:184:304219
Datum objave publikacije2019-09-16
ProjektŠifra: 260934
Naziv (engleski): Molecular mechanisms of persistent antigenic stimulation in cytomegalovirus infection
Kratica: CMVAGSTIMULUS
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttp://dx.plos.org/10.1371/journal.ppat.1008036
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-11-19 16:33:50