prikaz prve stranice dokumenta Combination of QF‐PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage
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Combination of QF‐PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage
Molecular Genetics & Genomic Medicine, (2019); e980. https://doi.org/10.1002/mgg3.980
Lovrečić, Luca; Pereza, Nina; Jaklič, Helena; Ostojić, Saša; Peterlin, Borut

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Lovrečić, L., Pereza, N., Jaklič, H., Ostojić, S. i Peterlin, B. (2019). Combination of QF‐PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage. Molecular Genetics & Genomic Medicine. doi: 10.1002/mgg3.980

Lovrečić, Luca, et al. "Combination of QF‐PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage." Molecular Genetics & Genomic Medicine, 2019. https://doi.org/10.1002/mgg3.980

Lovrečić, Luca, Nina Pereza, Helena Jaklič, Saša Ostojić i Borut Peterlin. "Combination of QF‐PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage." Molecular Genetics & Genomic Medicine (2019). https://doi.org/10.1002/mgg3.980

Lovrečić, L., et al. (2019) 'Combination of QF‐PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage', Molecular Genetics & Genomic Medicine. doi: 10.1002/mgg3.980

Lovrečić L, Pereza N, Jaklič H, Ostojić S, Peterlin B. Combination of QF‐PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage. Molecular Genetics & Genomic Medicine [Internet]. 23.10.2019. [pristupljeno 10.05.2024.]. doi: 10.1002/mgg3.980

L. Lovrečić, N. Pereza, H. Jaklič, S. Ostojić i B. Peterlin, "Combination of QF‐PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage", Molecular Genetics & Genomic Medicine, Listopad 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:593727. [Citirano: 10.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:593727
Podaci o radu
Naslov (engleski)Combination of QF‐PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage
AutorLuca Lovrečić
AutorNina Pereza
AutorHelena Jaklič
AutorSaša Ostojić
AutorBorut Peterlin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Abstract BACKGROUND: Our aim was to conduct a comprehensive genetic evaluation using the combination of QF-PCR (quantitative fluorescence polymerase chain reaction) and aCGH (array comparative genomic hybridization) for the detection of the frequency and type of chromosome aberrations in recurrent miscarriage (RM) in the clinical setting. METHODS: This retrospective study was conducted on 73 first-trimester products of conception (POC) between September 2014 and February 2017. The POCs were collected from 73 women with at least one previous miscarriage and analyzed for chromosomal anomalies using QF-PCR and aCGH as part of the routine clinical evaluation. RESULTS: Chromosome aberrations were detected in 52/73 POCs (71.2%), of which 41 (56.2%) were identified by QF-PCR and an additional 11 (15.1%) by aCGH. Numerical aberrations constituted 92.3% of abnormalities, with trisomies as the most common subtype (72.9%). Causative structural aberrations were found in three samples (5.8%). The frequency of chromosome aberrations was not dependent on the number of previous miscarriages, whereas it significantly increased with advanced maternal age. CONCLUSION: Our results confirm that chromosome aberrations are the most common cause of RM and that QF-PCR and aCGH combination should be included in the routine genetic analysis of POCs of couples with miscarriage
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objavePrihvaćen za objavljivanje
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecular Genetics & Genomic Medicine
Brojčani podacie980
p-ISSN2324-9269
e-ISSN2324-9269
DOIhttps://doi.org/10.1002/mgg3.980
URN:NBNurn:nbn:hr:184:593727
Datum objave publikacije2019-10-23
URL dokumentahttps://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.980
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2019-11-20 10:02:35