The basis for the action of anticoagulant and antiplatelet therapy is knowledge of the hemostasis process. This type of therapy is ordained by a family physician in many patients, so it is very important to know its properties. Atrial fibrillation and deep vein thrombosis are conditions that mostly cause clot formation. The risk assessment for clot formation is based on CHA2-DS2-VASc and HAS-BLED score scales in patients with atrial fibrillation. In family medicine, anti-platelet drugs that are ordered are acetylsalicylic acid and clopidogrel. By their action, these drugs prevent platelet aggregation and thus prevent the occurrence of thromboembolic incidents. Anticoagulant therapy in family medicine consists of warfarin and oral anticoagulants (dabigatran, rivaroxaban and apiksaban). Varfarin acts on the synthesis of vitamin K, while oral anticoagulants act on thrombin and factor Xa. Control of effectiveness of therapy is measured through INR. It is important to regularly monitor the patients in the form of information and stimulation of regular treatment and the evaluation of clinical parameters such as liver and kidney function and possible interactions with other drugs. Key words: hemostasis, atrial fibrillation, deep vein thrombosis, clotting, thromboembolic incident, antiaggregation therapy, anticoagulation therapy, risk assessment, patient monitoring, clinical parameter estimation.