Heart failure (HF) is the reason for the growing number of hospitalizations and is one of the leading causes of death in the world, especially Western countries. Although HF therapy has progressed enormously, a high percentage of deaths from this disease continue to be recorded. In the search for a better prediction of outcomes of patients with HF, we investigated the role of high sensitive troponin T (hs-TnT) and compared it with already proven marker of cardiac failure, N-terminal pro-B-type natriuretic peptide (NT-proBNP). In the period from 1.10.2017. to 1.4.2018. we analyzed the medical history of 315 patients hospitalized at KBC Rijeka due to acute decompensated heart failure (ADHF). Mortality was 14.9%, which is 1% less than 4 years earlier. Hs-TnT and NT-proBNP were significantly higher in nonsurvivors compared to survivors (p < 0.001). Significant elevations of hs-TnT and NT-proBNP were noticed in patients who had anaemia and chronic renal failure together with heart failure. NT-proBNP was predominantly elevated in Hf-rEF compared to hs-TnT which did not show significant differences according to ejection fraction. Unlike NT-proBNP, which did not show important differences between different NYHA grades (P = 0,112), hs-TnT was significantly elevated in NYHA IV compared to lower grades (P < 0.05). NT-proBNP values were predominantly elevated in patients older than 85 years compared to patients younger than 65 years. We can conclude that hs-TnT has proved to be an excellent predictor of outcome in patients with ADHF, especially with regard to anaemia, chronic renal failure and NYHA scale, while it's significance, with regard to ejection fraction, was equal among different values of ejection fractions.