Urinary tract infections are one of the most common bacterial infections in humans. Antibiotic treatment is effective in most cases, but disease often returns and there is a need for a milder solution in the form of herbal preparations that will keep the infections under control and thus reduce antibiotic use. One of the plants that has proven effective in the treatment and prevention of urinary infections is Arbutus unedo L. Strawberry tree is mostly found in southern Europe, dominated by Mediterranean climate. The leaves have been found to be abundant in various biochemical substances that have anti-aggregation, antidiarrheal, antidiabetic, anti-inflammatory and antiseptic effects on the urinary system. The main ingredient of the plant is arbutin, which, in the human body, is converted into hydroquinone, a bioactive molecule that actually has an antiseptic effect on the urinary system. The aim of this study was to determine the antibacterial properties of honey and leaf extracts of strawberry tree on selected bacterial strains that are most common cause of urinary infections, namely Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa and Klebsiella pneumoniae. The methods used were a diffusion method by drilling holes in agar and double microdilution method. The strongest antibacterial activity was shown in Enterococcus faecalis where the MIC was 1.6 mg / mL while honey in combination with the extract showed an additive effect. In conclusion, Arbutus unedo L. has shown significant results in antimicrobial action on uropathogenic bacteria, especially Enterococcus faecalis, and thus has great potential as an natural remedy in the treatment of urinary bacterial infections.