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Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity
PLOS Biology, 18 (2020), 3; e3000648. https://doi.org/10.1371/journal.pbio.3000648
Kavazović, Inga; Han, Hongya; Balzaretti, Giulia; Slinger, Erik; Lemmermann, Niels A. W.; ten Brinke, Anja; Merkler, Doron; Koster, Jan; Bryceson, Yenan T.; de Vries, Niek; Jonjić, Stipan; Klarenbeek, Paul L.; Polić, Bojan; Eldering, Eric; Wensveen, Felix M. Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Kavazović, I., Han, H., Balzaretti, G., Slinger, E., Lemmermann, N. A. W., ten Brinke, A. ... Wensveen, F. M. (2020). Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity. PLOS Biology, 18. (3). doi: 10.1371/journal.pbio.3000648

Kavazović, Inga, et al. "Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity." PLOS Biology, vol. 18, br. 3, 2020. https://doi.org/10.1371/journal.pbio.3000648

Kavazović, Inga, Hongya Han, Giulia Balzaretti, Erik Slinger, Niels A. W. Lemmermann, Anja ten Brinke, Doron Merkler, et al. "Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity." PLOS Biology 18, br. 3 (2020). https://doi.org/10.1371/journal.pbio.3000648

Kavazović, I., et al. (2020) 'Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity', PLOS Biology, 18(3). doi: 10.1371/journal.pbio.3000648

Kavazović I, Han H, Balzaretti G, Slinger E, Lemmermann NAW, ten Brinke A, i sur.. Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity. PLOS Biology [Internet]. 17.03.2020. [pristupljeno 07.11.2024.];18(3). doi: 10.1371/journal.pbio.3000648

I. Kavazović, et al., "Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity", PLOS Biology, vol. 18, br. 3, Ožujak 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:950480. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:950480
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Naslov (engleski)Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity
AutorInga Kavazović
AutorHongya Han
AutorGiulia Balzaretti
AutorErik Slinger
AutorNiels A. W. Lemmermann
AutorAnja ten Brinke
AutorDoron Merkler
AutorJan Koster
AutorYenan T. Bryceson
AutorNiek de Vries
AutorStipan Jonjić
AutorPaul L. Klarenbeek
AutorBojan Polić
AutorEric Eldering
AutorFelix M. Wensveen
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epitopes. How the level of diversity within the memory pool is controlled is unclear, especially in the context of a selective drive for antigen affinity. We find that preservation of clones that bind the activating antigen with low affinity depends on expression of the transcription factor Eomes in the first days after antigen encounter. Eomes is induced at low activating signal strength and directly drives transcription of the prosurvival protein Bcl-2. At higher signal intensity, T-bet is induced which suppresses Bcl-2 and causes a relative survival advantage for cells of low affinity. Clones activated with high-affinity antigen form memory largely independent of Eomes and have a proliferative advantage over clones that bind the same antigen with low affinity. This causes high-affinity clones to prevail in the memory pool, despite their relative survival deficit. Genetic or therapeutic targeting of the Eomes/Bcl-2 axis reduces the clonal diversity of the memory pool, which diminishes its ability to respond to pathogens carrying mutations in immunodominant epitopes. Thus, we demonstrate on a molecular level how sufficient diversity of the memory pool is established in an environment of affinity-based selection.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLOS Biology
Brojčani podacivol. 18, br. 3, e3000648
e-ISSN1545-7885
DOIhttps://doi.org/10.1371/journal.pbio.3000648
URN:NBNurn:nbn:hr:184:950480
Datum objave publikacije2020-03-17
ProjektŠifra: IP-2016-06-8027
Naziv (hrvatski): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Kratica: T-MEMORY
Voditelj: Felix Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-2016-06-9306
Naziv (hrvatski): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Kratica: INFLAMETAB
Voditelj: Bojan Polić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: ERDF
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttps://dx.plos.org/10.1371/journal.pbio.3000648
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-03-23 16:48:12