prikaz prve stranice dokumenta Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity
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Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity
Oxidative Medicine and Cellular Longevity, 2020 (2020); 1-20. https://doi.org/10.1155/2020/6125638
Giacometti, Jasminka; Grubić Kezele, Tanja

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Giacometti, J. i Grubić Kezele, T. (2020). Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity. Oxidative Medicine and Cellular Longevity, 2020., 1-20. doi: 10.1155/2020/6125638

Giacometti, Jasminka i Tanja Grubić Kezele. "Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity." Oxidative Medicine and Cellular Longevity, vol. 2020, 2020, str. 1-20. https://doi.org/10.1155/2020/6125638

Giacometti, Jasminka i Tanja Grubić Kezele. "Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity." Oxidative Medicine and Cellular Longevity 2020 (2020): 1-20. https://doi.org/10.1155/2020/6125638

Giacometti, J. i Grubić Kezele, T. (2020) 'Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity', Oxidative Medicine and Cellular Longevity, 2020, str. 1-20. doi: 10.1155/2020/6125638

Giacometti J, Grubić Kezele T. Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity. Oxidative Medicine and Cellular Longevity [Internet]. 31.07.2020. [pristupljeno 18.05.2024.];2020:1-20. doi: 10.1155/2020/6125638

J. Giacometti i T. Grubić Kezele, "Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity", Oxidative Medicine and Cellular Longevity, vol. 2020, str. 1-20, Srpanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:763614. [Citirano: 18.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:763614
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Naslov (engleski)Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity
AutorJasminka Giacometti
AutorTanja Grubić Kezele
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Sažetak (engleski)
Numerous evidences suggest that plant polyphenols may have therapeutic benefits in regulating oxidative stress and providing neuroprotection in many neurodegenerative diseases, including multiple sclerosis (MS). However, these mechanisms are not yet completely understood. In this study, we investigated the effect of olive leaf polyphenols on oxidative stress through oxidation marker level and activity (TBARS, SOD, and GPX) and their protein expression (SOD1, SOD2, and GPX1), as well as the protein expression of Sirtuin 1 (SIRT1) and microglia markers (Iba-1, CD206, and iNOS) and myelin integrity (proteolipid protein expression) in the brain of rats with induced experimental autoimmune encephalomyelitis (EAE) and subjected to olive leaf therapy. Experiments were performed in male EAE DA rats, which were randomly divided into 2 main groups: EAE groups treated with the therapy of olive leaf (EAE+TOL) and untreated EAE control groups. The EAE treated groups consumed olive leaf tea instead of drinking water ( ) from the beginning to the end of the experiment. In addition, olive leaf extract was injected intraperitoneally ( .) for the 10 continuous days and started on the 8 day after EAE induction. The clinical course was monitored in both groups until the 30 day after EAE induction. Our results demonstrated that TOL attenuated the clinical course of EAE; reduced the oxidative stress (by decreasing the concentration of MDA); upregulated antioxidant enzymes (SOD1, SOD2, and GPX1), SIRT1 (overall and microglial), and anti-inflammatory M2 microglia; downregulated proinflammatory M1 type; and preserved myelin integrity. These data support the idea that TOL may be an effective therapeutic approach for treating MS and other neurodegenerative diseases.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaOxidative Medicine and Cellular Longevity
Brojčani podacivol. 2020, str. 1-20, 6125638
p-ISSN1942-0900
e-ISSN1942-0994
DOIhttps://doi.org/10.1155/2020/6125638
URN:NBNurn:nbn:hr:184:763614
Datum objave publikacije2020-07-31
URL dokumentahttps://www.hindawi.com/journals/omcl/2020/6125638/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-09-17 12:07:02