prikaz prve stranice dokumenta Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila
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Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila
International Journal of Molecular Sciences, 21 (2020), 15; 5367. https://doi.org/10.3390/ijms21155367
Lesar, Andrija; Mušković, Martina; Begić, Gabrijela; Lončarić, Martin; Tomić Linšak, Dijana; Malatesti, Nela; Gobin, Ivana

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Lesar, A., Mušković, M., Begić, G., Lončarić, M., Tomić Linšak, D., Malatesti, N. i Gobin, I. (2020). Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila. International Journal of Molecular Sciences, 21. (15). doi: 10.3390/ijms21155367

Lesar, Andrija, et al. "Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila." International Journal of Molecular Sciences, vol. 21, br. 15, 2020. https://doi.org/10.3390/ijms21155367

Lesar, Andrija, Martina Mušković, Gabrijela Begić, Martin Lončarić, Dijana Tomić Linšak, Nela Malatesti i Ivana Gobin. "Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila." International Journal of Molecular Sciences 21, br. 15 (2020). https://doi.org/10.3390/ijms21155367

Lesar, A., et al. (2020) 'Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila', International Journal of Molecular Sciences, 21(15). doi: 10.3390/ijms21155367

Lesar A, Mušković M, Begić G, Lončarić M, Tomić Linšak D, Malatesti N, i sur.. Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila. International Journal of Molecular Sciences [Internet]. 28.07.2020. [pristupljeno 23.11.2024.];21(15). doi: 10.3390/ijms21155367

A. Lesar, et al., "Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila", International Journal of Molecular Sciences, vol. 21, br. 15, Srpanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:510066. [Citirano: 23.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:510066
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Naslov (engleski)Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella pneumophila
AutorAndrija Lesar
AutorMartina Mušković
AutorGabrijela Begić
AutorMartin Lončarić
AutorDijana Tomić Linšak
AutorNela Malatesti
AutorIvana Gobin
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zdravstvenu ekologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Sažetak (engleski)
Legionella pneumophila is an environmental bacterium, an opportunistic premise plumbing pathogen that causes the Legionnaires’ disease. L. pneumophila presents a serious health hazard in building water systems, due to its high resistance to standard water disinfection methods. Our aim was to study the use of photodynamic inactivation (PDI) against Legionella. We investigated and compared the photobactericidal potential of five cationic dyes. We tested toluidine blue (TBO) and methylene blue (MB), and three 3-N-methylpyridylporphyrins, one tetra-cationic and two tri-cationic, one with a short (CH3) and the other with a long (C17H35) alkyl chain, against L. pneumophila in tap water and after irradiation with violet light. All tested dyes demonstrated a certain dark toxicity against L. pneumophila; porphyrins with lower minimal effective concentration (MEC) values than TBO and MB. Nanomolar MEC values, significantly lower than with TBO and MB, were obtained with all three porphyrins in PDI experiments, with amphiphilic porphyrin demonstrating the highest PDI activity. All tested dyes showed increasing PDI with longer irradiation (0–108 J/cm2), especially the two hydrophilic porphyrins. All three porphyrins caused significant changes in cell membrane permeability after irradiation and L. pneumophila, co-cultivated with Acanthamoeba castellanii after treatment with all three porphyrins and irradiation, did not recover in amoeba. We believe our results indicate the considerable potential of cationic porphyrins as effective anti-Legionella agents.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 21, br. 15, 5367
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms21155367
URN:NBNurn:nbn:hr:184:510066
Datum objave publikacije2020-07-28
URL dokumentahttps://www.mdpi.com/1422-0067/21/15/5367
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-09-28 15:02:36