Organ donation and transplantation is one of the greatest achievements of medicine in the last sixty years. The development of transplantation medicine depends on the socio-economical, cultural and religious determinants of the particular place. Based on the research, we can say that transplantation medicine is very sensitive with regards to the other fields of medicine. Transplantation medicine inevitably binds ethical doubts, but also legal, cultural and religious dilemmas. The transplantation medicine implies also the question of the death moment. The concept of death is an entity, which preoccupies the artists, scientists, ethicists and medical professionals from the beginning of human civilization. At the beginning of 21st century, we testify the changes on the global social plan, big migration of population which bring with them the clash of civilization, ethics and religion. Therefore, it is necessary to explore the attitude of different religions toward the organ transplantation and donation in the light of today’s social events. The majority of world religions have positive attitudes towards the organ transplantation and xenotransplantation. In this paper, we will explore the attitude of different religions towards organ donation and transplantation and towards xenotransplantation. For the further research there are other religions and world communities and their attitudes regarding the organ donation which are not mentioned in this paper.