prikaz prve stranice dokumenta NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
  Preuzmi
PDF 5.59 MB
Znanstveni rad - Izvorni znanstveni rad
NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
Journal of Experimental Medicine, 217 (2020), 8; e20190133. https://doi.org/10.1084/jem.20190133
Babić, Marina; Dimitropoulos, Christoforos; Hammer, Quirin; Stehle, Christina; Heinrich, Frederik; Sarsenbayeva, Assel; Eisele, Almut; Durek, Pawel; Mashreghi, Mir-Farzin; Lisnić, Berislav; Van Snick, Jacques; Löhning, Max; Fillatreau, Simon; Withers, David R.; Gagliani, Nicola; Huber, Samuel; Flavell, Richard A.; Polić, Bojan; Romagnani, Chiara Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Babić, M., Dimitropoulos, C., Hammer, Q., Stehle, C., Heinrich, F., Sarsenbayeva, A. ... Romagnani, C. (2020). NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells. Journal of Experimental Medicine, 217. (8). doi: 10.1084/jem.20190133

Babić, Marina, et al. "NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells." Journal of Experimental Medicine, vol. 217, br. 8, 2020. https://doi.org/10.1084/jem.20190133

Babić, Marina, Christoforos Dimitropoulos, Quirin Hammer, Christina Stehle, Frederik Heinrich, Assel Sarsenbayeva, Almut Eisele, et al. "NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells." Journal of Experimental Medicine 217, br. 8 (2020). https://doi.org/10.1084/jem.20190133

Babić, M., et al. (2020) 'NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells', Journal of Experimental Medicine, 217(8). doi: 10.1084/jem.20190133

Babić M, Dimitropoulos C, Hammer Q, Stehle C, Heinrich F, Sarsenbayeva A, i sur.. NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells. Journal of Experimental Medicine [Internet]. 03.08.2020. [pristupljeno 07.11.2024.];217(8). doi: 10.1084/jem.20190133

M. Babić, et al., "NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells", Journal of Experimental Medicine, vol. 217, br. 8, Kolovoz 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:299388. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:299388
Podaci o radu
Naslov (engleski)NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
AutorMarina Babić
AutorChristoforos Dimitropoulos
AutorQuirin Hammer
AutorChristina Stehle
AutorFrederik Heinrich
AutorAssel Sarsenbayeva
AutorAlmut Eisele
AutorPawel Durek
AutorMir-Farzin Mashreghi
AutorBerislav Lisnić
AutorJacques Van Snick
AutorMax Löhning
AutorSimon Fillatreau
AutorDavid R. Withers
AutorNicola Gagliani
AutorSamuel Huber
AutorRichard A. Flavell
AutorBojan Polić
AutorChiara Romagnani
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
NKG2D is a danger sensor expressed on different subsets of innate and adaptive lymphocytes. Despite its established role as a potent activator of the immune system, NKG2D-driven regulation of CD4+ T helper (Th) cell–mediated immunity remains unclear. In this study, we demonstrate that NKG2D modulates Th1 and proinflammatory T-bet+ Th17 cell effector functions in vitro and in vivo. In particular, NKG2D promotes higher production of proinflammatory cytokines by Th1 and T-bet+ Th17 cells and reinforces their transcription of type 1 signature genes, including Tbx21. Conditional deletion of NKG2D in T cells impairs the ability of antigen-specific CD4+ T cells to promote inflammation in vivo during antigen-induced arthritis and experimental autoimmune encephalomyelitis, indicating that NKG2D is an important target for the amelioration of Th1- and Th17-mediated chronic inflammatory diseases.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Experimental Medicine
Brojčani podacivol. 217, br. 8, e20190133
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20190133
URN:NBNurn:nbn:hr:184:299388
Datum objave publikacije2020-08-03
ProjektŠifra: IP-2016-06-9306
Naziv (hrvatski): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Kratica: INFLAMETAB
Voditelj: Bojan Polić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://rupress.org/jem/article/doi/10.1084/jem.20190133/151818/NK-cell-receptor-NKG2D-enforces-proinflammatory
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2021-03-09 09:51:51