Vascular access infections are defined by local pain, pus and redness, or, in the absence of such symptoms, a positive blood culture. Infection is the most dangerous complication related to vascular access. It accounts for about 20% of total mortality rate in patients with end stage chronic kideny disease. The use of central venous catheter is associated with more common vascular access infections compared to arteriovenour fistula od arteriovenous graft. Vascular access infections are most commonly associated with gram – positive staphylococci. The aim of this study was to investigate the epidemiology and association of diabetes with vascular access infections in dialysis patients, the frequency of vascular access infections with respect to the type of vascular access. The study was conducted on 144 patients treated with hemodialysis at the Department of Nephrology and Dialysis, Clinical Hospital Center Rijeka in the period from March 1 to August 31, 2020. Data was collected retrospectively. The incidence of vascular access infections was 7.6 per 100 patients over a 6-month period. central venous catheter was associated with a higher incidence of circulatory access infections (72,73%), and S. aureus and coagulase-negative staphylococci were identified as the most common causes. No statistically significant association was found between diabetes and the risk of developing a circulatory access infection.