prikaz prve stranice dokumenta A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma
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A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma
Experimental Biology and Medicine, 242 (2017), 15; 1553-1558. https://doi.org/10.1177/1535370217724093
Franzoni, Alessandra; Markova-Car, Elitza; Dević-Pavlić, Sanja; Jurišić, Davor; Puppin, Cinzia; Mio, Catia; De Luca, Marila; Petruz, Giulia; Damante, Giuseppe; Kraljević Pavelić, Sandra

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Franzoni, A., Markova Car, E., Dević Pavlić, S., Jurišić, D., Puppin, C., Mio, C. ... Kraljević Pavelić, S. (2017). A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma. Experimental Biology and Medicine, 242. (15), 1553-1558. doi: 10.1177/1535370217724093

Franzoni, Alessandra, et al. "A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma." Experimental Biology and Medicine, vol. 242, br. 15, 2017, str. 1553-1558. https://doi.org/10.1177/1535370217724093

Franzoni, Alessandra, Elitza Markova Car, Sanja Dević Pavlić, Davor Jurišić, Cinzia Puppin, Catia Mio, Marila De Luca, Giulia Petruz, Giuseppe Damante i Sandra Kraljević Pavelić. "A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma." Experimental Biology and Medicine 242, br. 15 (2017): 1553-1558. https://doi.org/10.1177/1535370217724093

Franzoni, A., et al. (2017) 'A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma', Experimental Biology and Medicine, 242(15), str. 1553-1558. doi: 10.1177/1535370217724093

Franzoni A, Markova Car E, Dević Pavlić S, Jurišić D, Puppin C, Mio C, i sur.. A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma. Experimental Biology and Medicine [Internet]. 2017. [pristupljeno 14.05.2024.];242(15):1553-1558. doi: 10.1177/1535370217724093

A. Franzoni, et al., "A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma", Experimental Biology and Medicine, vol. 242, br. 15, str. 1553-1558, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:966552. [Citirano: 14.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:966552
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Naslov (engleski)A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma
AutorAlessandra Franzoni
AutorElitza Markova-Car
AutorSanja Dević-Pavlić
MBZ: 320360
AutorDavor Jurišić
MBZ: 280602
AutorCinzia Puppin
AutorCatia Mio
AutorMarila De Luca
AutorGiulia Petruz
AutorGiuseppe Damante
AutorSandra Kraljević Pavelić
MBZ: 254965
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kirurgiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		INTERDISCIPLINARNA PODRUČJA ZNANOSTI
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Circadian clock regulation in mammals is controlled by feedback loops of a set of circadian genes. One of these circadian genes, NPAS2, encodes for a member of the bHLH-PAS class of transcription factors and is expressed in the forebrain and in some peripheral organs such as liver and skin. Other biological processes are also regulated by circadian genes. For example, NPAS2 is involved in cell proliferation, DNA damage repair and malignant transformation. Aberrant expression of clock genes has been previously observed in melanoma which led to our effort to sequence the NPAS2 promoter region in this cancer type. The NPAS2 putative promoter and 5′ untranslated region of ninety-three melanoma patients and ninety-six control subjects were sequenced and several variants were identified. Among these is a novel microsatellite comprising a GGC repeat with different alleles ranging from 7 to 13 repeats located in the 5′ untranslated exon. Homozygosity of an allele with nine repeats (9/9) was more prevalent in melanoma than in control subjects (22.6% and 13.5%, respectively, P: 0.0206) suggesting that some NPAS2 variants might contribute to melanoma susceptibility.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaExperimental Biology and Medicine
Brojčani podacivol. 242, br. 15, str. 1553-1558
p-ISSN1535-3702
e-ISSN1535-3699
DOIhttps://doi.org/10.1177/1535370217724093
URN:NBNurn:nbn:hr:184:966552
Datum objave publikacije2017
URL dokumentahttp://bib.irb.hr/894974
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-03 10:43:06