prikaz prve stranice dokumenta An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population
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An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population
Prostaglandins leukotrienes and essential fatty acids, 121 (2017); 57-59. https://doi.org/10.1016/j.plefa.2017.06.003
Nadalin, Sergej; Buretić-Tomljanović, Alena

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Nadalin, S. i Buretić Tomljanović, A. (2017). An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population. Prostaglandins leukotrienes and essential fatty acids, 121., 57-59. doi: 10.1016/j.plefa.2017.06.003

Nadalin, Sergej i Alena Buretić Tomljanović. "An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population." Prostaglandins leukotrienes and essential fatty acids, vol. 121, 2017, str. 57-59. https://doi.org/10.1016/j.plefa.2017.06.003

Nadalin, Sergej i Alena Buretić Tomljanović. "An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population." Prostaglandins leukotrienes and essential fatty acids 121 (2017): 57-59. https://doi.org/10.1016/j.plefa.2017.06.003

Nadalin, S. i Buretić Tomljanović, A. (2017) 'An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population', Prostaglandins leukotrienes and essential fatty acids, 121, str. 57-59. doi: 10.1016/j.plefa.2017.06.003

Nadalin S, Buretić Tomljanović A. An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population. Prostaglandins leukotrienes and essential fatty acids [Internet]. 2017. [pristupljeno 10.05.2024.];121:57-59. doi: 10.1016/j.plefa.2017.06.003

S. Nadalin i A. Buretić Tomljanović, "An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population", Prostaglandins leukotrienes and essential fatty acids, vol. 121, str. 57-59, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:512171. [Citirano: 10.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:512171
Podaci o radu
Naslov (engleski)An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population
AutorSergej Nadalin
AutorAlena Buretić-Tomljanović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
We investigated the allele and genotype frequency of the rs4375 and rs1549637 polymorphisms in phospholipase A2 (PLA2)G6 and PLA2G4C genes in 203 patients with schizophrenia and 191 controls in a Croatian population. We hypothesized that these polymorphic variations might influence the age of schizophrenia onset and Positive and Negative Syndrome Scale psychopathology (PANSS) data. We detected a significant overrepresentation of the PLA2G6-CT and PLA2G4C-AT genotype combination in patients compared with controls (14.7% vs. 7.3%, P < 0.05). The combined PLA2G6/PLA2G4C heterozygosity was associated with about a two-fold higher schizophrenia risk. We found no significant influence of the PLA2G6 and PLA2G4C polymorphisms on mean age at first hospital admission (P > 0.05) and that the investigated polymorphisms significantly influenced the clinical psychopathology only in male patients. The PLA2G4C polymorphism accounted for approximately 12% of negative symptom severity ; whereas, the PLA2G6/PLA2G4C interaction contributed to a similar extent to total PANSS symptom variations.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProstaglandins leukotrienes and essential fatty acids
Brojčani podacivol. 121, str. 57-59
p-ISSN0952-3278
DOIhttps://doi.org/10.1016/j.plefa.2017.06.003
URN:NBNurn:nbn:hr:184:512171
Datum objave publikacije2017
URL dokumentahttp://bib.irb.hr/882222
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-07 11:47:28