prikaz prve stranice dokumenta Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation
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Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation
Phytotherapy research, 32 (2018), 6; 1090-1097. urn:nbn:hr:184:306189
Potočnjak, Iva; Gobin, Ivana; Domitrović, Robert

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Potočnjak, I., Gobin, I. i Domitrović, R. (2018). Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation. Phytotherapy research, 32. (6), 1090-1097. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:306189

Potočnjak, Iva, et al. "Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation." Phytotherapy research, vol. 32, br. 6, 2018, str. 1090-1097. https://urn.nsk.hr/urn:nbn:hr:184:306189

Potočnjak, Iva, Ivana Gobin i Robert Domitrović. "Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation." Phytotherapy research 32, br. 6 (2018): 1090-1097. https://urn.nsk.hr/urn:nbn:hr:184:306189

Potočnjak, I., Gobin, I. i Domitrović, R. (2018) 'Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation', Phytotherapy research, 32(6), str. 1090-1097. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:306189 (Datum pristupa: 27.04.2024.)

Potočnjak I, Gobin I, Domitrović R. Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation. Phytotherapy research [Internet]. 2018. [pristupljeno 27.04.2024.];32(6):1090-1097. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:306189

I. Potočnjak, I. Gobin i R. Domitrović, "Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation", Phytotherapy research, vol. 32, br. 6, str. 1090-1097, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:306189. [Citirano: 27.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:306189
Podaci o radu
Naslov (engleski)Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation
AutorIva Potočnjak
AutorIvana Gobin
AutorRobert Domitrović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Carvacrol has been shown to possess anticancer activity but the mechanism is unknown, as well as the possibility of interaction with anticancer drugs. The aim of this study was to investigate the role of mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling in carvacrol-induced human cervical cancer HeLa cell cytotoxicity. In addition, we studied sensitization of HeLa cells to cisplatin (CP) by carvacrol. Both carvacrol and CP showed dose-dependent cytotoxicity against HeLa cells and activated ERK1/2. The MEK inhibitor PD325901 suppressed ERK expression and further increased cytotoxicity of carvacrol but increased viability of CP-treated cells by modulating apoptosis. The MEK inhibitor also increased microtubule-associated protein 1A/1B- light chain 3 (LC3B) expression in CP treatment. Co-treatment with CP and carvacrol resulted in increased viability of the cancer cells compared to CP treatment, which was associated with the suppression of apoptosis. MEK inhibition decreased the cell viability, without changes in apoptosis. Concomitantly, carvacrol increased CP-induced expression of LC3B, which was enhanced by MEK inhibition. The results of the current study suggest the opposite role of ERK1/2 in carvacrol and CP- induced HeLa cell cytotoxicity. Interestingly, carvacrol induced CP resistance in HeLa cells through ERK1/2-independent suppression of apoptosis and ERK1/2-dependent modulation of autophagy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPhytotherapy research
Brojčani podacivol. 32, br. 6, str. 1090-1097
p-ISSN0951-418X
URN:NBNurn:nbn:hr:184:306189
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/918181
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-09 15:57:46