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Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)
Genes, 10 (2019); 783. https://doi.org/10.3390/genes10100783
Ozretić, Petar; da Silva Filho, Miguel Inacio; Catalano, Calogerina; Sokolović, Irena; Vukić-Dugac, Andrea; Šutić, Maja; Kurtović, Matea; Bubanović, Gordana; Popović-Grle, Sanja; Skrinjarić-Cincar, Sanda; Vugrek, Oliver; Jukić, Irena; Rumora, Lada; Bosnar, Martina; Samaržija, Miroslav; Bals, Robert; Jakopović, Marko; Försti, Asta; Knežević, Jelena Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Ozretić, P., da Silva Filho, M. I., Catalano, C., Sokolović, I., Vukić Dugac, A., Šutić, M. ... Knežević, J. (2019). Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Genes, 10.. doi: 10.3390/genes10100783

Ozretić, Petar, et al. "Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)." Genes, vol. 10, 2019. https://doi.org/10.3390/genes10100783

Ozretić, Petar, Miguel Inacio da Silva Filho, Calogerina Catalano, Irena Sokolović, Andrea Vukić Dugac, Maja Šutić, Matea Kurtović, et al. "Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)." Genes 10 (2019). https://doi.org/10.3390/genes10100783

Ozretić, P., et al. (2019) 'Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)', Genes, 10. doi: 10.3390/genes10100783

Ozretić P, da Silva Filho MI, Catalano C, Sokolović I, Vukić Dugac A, Šutić M, i sur.. Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Genes [Internet]. 2019. [pristupljeno 23.12.2024.];10. doi: 10.3390/genes10100783

P. Ozretić, et al., "Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)", Genes, vol. 10, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:898837. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:898837
Podaci o radu
Naslov (engleski)Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)
AutorPetar Ozretić
MBZ: 295840
AutorMiguel Inacio da Silva Filho
AutorCalogerina Catalano
AutorIrena Sokolović
AutorAndrea Vukić-Dugac
MBZ: 353752
AutorMaja Šutić
MBZ: 362344
AutorMatea Kurtović
MBZ: 372843
AutorGordana Bubanović
MBZ: 319765
AutorSanja Popović-Grle
MBZ: 153353
AutorSanda Skrinjarić-Cincar
MBZ: 129630
AutorOliver Vugrek
MBZ: 232935
AutorIrena Jukić
MBZ: 341464
AutorLada Rumora
MBZ: 205261
AutorMartina Bosnar
MBZ: 321473
AutorMiroslav Samaržija
MBZ: 146943
AutorRobert Bals
AutorMarko Jakopović
MBZ: 278365
AutorAsta Försti
AutorJelena Knežević
MBZ: 242431
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by a progressive decline in lung function due to airflow limitation, mainly related to IL-1β-induced inflammation. We have hypothesized that single nucleotide polymorphisms (SNPs) in NLRP genes, coding for key regulators of IL-1β, are associated with pathogenesis and clinical phenotypes of COPD. We recruited 704 COPD individuals and 1238 healthy controls for this study. Twenty non-synonymous SNPs in 10 different NLRP genes were genotyped. Genetic associations were estimated using logistic regression, adjusting for age, gender, and smoking history. The impact of genotypes on patients’ overall survival was analyzed with the Kaplan–Meier method with the log-rank test. Serum IL-1β concentration was determined by high sensitivity assay and expression analysis was done by RT-PCR. Decreased lung function, measured by a forced expiratory volume in 1 s (FEV1% predicted), was significantly associated with the minor allele genotypes (AT + TT) of NLRP1 rs12150220 (p = 0.0002). The same rs12150220 genotypes exhibited a higher level of serum IL-1β compared to the AA genotype (p = 0.027) in COPD patients. NLRP8 rs306481 minor allele genotypes (AG + AA) were more common in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) definition of group A (p = 0.0083). Polymorphisms in NLRP1 (rs12150220 ; OR = 0.55, p = 0.03) and NLRP4 (rs12462372 ; OR = 0.36, p = 0.03) were only nominally associated with COPD risk. In conclusion, coding polymorphisms in NLRP1 rs12150220 show an association with COPD disease severity, indicating that the fine-tuning of the NLRP1 inflammasome could be important in maintaining lung tissue integrity and treating the chronic inflammation of airways.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGenes
Brojčani podacivol. 10, 783
p-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes10100783
URN:NBNurn:nbn:hr:184:898837
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1025843
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-10 17:04:56