prikaz prve stranice dokumenta Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract
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Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract
Toxicology and Applied Pharmacology, 383 (2019); 1-10. https://doi.org/10.1016/j.taap.2019.114784
Rinčic Mlinarić, Marijana; Durgo, Ksenija; Katić, Višnja; Špalj, Stjepan

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Rinčic Mlinarić, M., Durgo, K., Katić, V. i Špalj, S. (2019). Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract. Toxicology and Applied Pharmacology, 383., 1-10. doi: 10.1016/j.taap.2019.114784

Rinčic Mlinarić, Marijana, et al. "Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract." Toxicology and Applied Pharmacology, vol. 383, 2019, str. 1-10. https://doi.org/10.1016/j.taap.2019.114784

Rinčic Mlinarić, Marijana, Ksenija Durgo, Višnja Katić i Stjepan Špalj. "Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract." Toxicology and Applied Pharmacology 383 (2019): 1-10. https://doi.org/10.1016/j.taap.2019.114784

Rinčic Mlinarić, M., et al. (2019) 'Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract', Toxicology and Applied Pharmacology, 383, str. 1-10. doi: 10.1016/j.taap.2019.114784

Rinčic Mlinarić M, Durgo K, Katić V, Špalj S. Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract. Toxicology and Applied Pharmacology [Internet]. 2019. [pristupljeno 15.05.2024.];383:1-10. doi: 10.1016/j.taap.2019.114784

M. Rinčic Mlinarić, K. Durgo, V. Katić i S. Špalj, "Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract", Toxicology and Applied Pharmacology, vol. 383, str. 1-10, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:664769. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:664769
Podaci o radu
Naslov (engleski)Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract
AutorMarijana Rinčic Mlinarić
MBZ: 340812
AutorKsenija Durgo
MBZ: 226422
AutorVišnja Katić
AutorStjepan Špalj
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ortodonciju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Sažetak (engleski)
The aim was to explore the biological effect of nickel (Ni) and titanium (Ti) ions released from dental alloys. NiTi alloy were exposed to 40 mL of artificial saliva (pH = 4.8, t = 37 °C). The dynamics of Ni and Ti ions release during corrosion were recorded on the 3th, 7th and 14th day. Biological effect of Ni and Ti ions released from alloy was explored on cell lines of human tongue CAL 27, liver Hep G2 and colon Caco-2. Neutral Red uptake assay for the estimation of cell viability/cytotoxicity and 2′, 7′- dichlorofluorescein diacetate fluorimetric assay for reactive oxygen species were used. Cells were exposed to the following concentration of corrosion products: 5.0×, 1.0×, 0.5 and 0.1× during the period of 24, 48 and 72 h. To check the effect of each metal separately, cells were exposed to nickel-chloride and titanium-dioxide of corresponding concentration. The release of Ni is higher than of Ti (15.1– 30.4 μg/L for Ni and 9.0–17.3 μg/L for Ti, respectively) and 5× higher concentrations are needed to induce cytotoxic effect. Ni and Ti ions alone do not induce a major cytotoxic effect, but their combination does indicating their synergistic effect. Increase in concentration of Ni and Ti tends to increase cytotoxicity, Ti more than Ni. Cytotoxicity and induction of free radicals are in strong positive linear correlation. Ions released from NiTi alloy during 14 days do not induce significant cytotoxic effect and would not have a clinically important impact. Cytotoxic effect is largely the result of the induction of free radicals.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaToxicology and Applied Pharmacology
Brojčani podacivol. 383, str. 1-10
p-ISSN0041-008X
DOIhttps://doi.org/10.1016/j.taap.2019.114784
URN:NBNurn:nbn:hr:184:664769
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1029896
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-15 17:10:12